The paper examines how physical activity interacts with genetic liability for adiposity to influence hypertension risk in UK Biobank participants, finding a protective effect in European ancestry individuals.

medRxiv · Sep 22, 2023 · PreprintGenetic & Genomic Medicine

Evidence for Involvement of WDPCP Gene in Alcohol Consumption, Lipid Metabolism, and Liver Cirrhosis

Felix O’Farrell, Benjamin Aleyakpo, Rima Mustafa, Xiyun Jiang, Rui Climaco Pinto, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan, Samantha H. Y. Loh, Jeff W. Barclay, L. Miguel Martins, Raha Pazoki

The paper investigates the role of WDPCP in alcohol consumption, lipid metabolism, and liver cirrhosis using human and model organism studies.

bioRxiv · Apr 11, 2023 · PreprintGenetics

Phenome-wide and Genome-wide Analyses of Quality of Life in Schizophrenia

Raha Pazoki, Bochao Danae Lin, Kristel R. van Eijk, Dick Schijven, Sonja M. C. de Zwarte, GROUP Investigators, Sinan Gülöksüz, Jurjen Justin Luykx

The paper identifies nine clinical phenotypes and polygenic risk scores associated with quality of life in schizophrenia patients and their relatives.

BJPsych Open · Dec 9, 2020Peer-reviewedGenetics

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand Floriaan Schmidt, Michael Vaclav Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, R Thomas Lumbers, Albert Henry, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, , Albert Hofman D

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

BMC Cardiovascular Disorders · Oct 29, 2019Peer-reviewedGenetics

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

Εvangelos Εvangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, İbrahim Karaman, Joshua Elliott, Stefanie Aeschbacher, Traci M. Bartz, Sebastian Edgar Baumeister, , Paul Elliott

This study identifies 46 novel genetic loci associated with alcohol consumption and suggests shared genetic mechanisms with neuropsychiatric disorders using GWAS and functional analyses.

bioRxiv · Oct 30, 2018 · PreprintGenetics

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

Foram N. Ashar, Rebecca N. Mitchell, Christine M. Albert, Christopher Newton‐Cheh, Jennifer A. Brody, Martina Müller‐Nurasyid, Anna Moes, Thomas Meitinger, Angel C. Y. Mak, Heikki V. Huikuri, Juhani M. Junttila, Philippe Goyette, Sara L. Pulit, Raha Pazoki, Michael W.T. Tanck, , Nona Sotoodehnia

This study evaluates the genetic architecture of sudden cardiac arrest through GWAS and Mendelian randomization, finding genetic correlations with CAD, height, BMI, and electrical instability traits.

European Heart Journal · Jul 20, 2018Peer-reviewedGenetics

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano A, William David Hill, Saskia P. Hagenaars, Stuart James Ritchie, Riccardo Emilio Marioni, Chloe Fawns‐Ritchie, David C M Liewald, Judith A. Okely, Ari Ahola‐Olli, Catriona L. K. Barnes, Lars Bertram, , Luca Kleineidam

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Nature Communications · May 22, 2018Peer-reviewedGenetics