bioRxivImmunologyPreprint
Ibrutinib modulates CD19 expression and improves efficacy of CD19-CAR T cells in B-cell lymphoma models
Sisi Wang, Alberto J. ArribasiD, Chiara TarantelliiD, Elisa CivanelliiD, Guangyu Zhou, Pragallabh Purwar, Amandine Pradier, Astrid Melotti, Francesca GuidettiiD, Yara Hajj Younes, Lodovico Terzi di BergamoiD, Luciano CascioneiD, Sara NapoliiD, Emanuele ZuccaiD, Elena SotilloiD, Crystal Lee MackalliD, Manel EstelleriD, Yves ChalandoniD, Davide RossiiD, Federico SimonettaiD, Francesco BertoniiD
Abstract
Antigen density critically influences CAR T-cell efficacy. We show that ibrutinib induces CD19 upregulation in B-cell lymphoma models, enhancing CAR T-cell cytotoxicity. Pharmacologic modulation of target antigen expression represents a promising strategy to overcome resistance.
- organism: mouse
- assay: bulk RNA-seq
- research focus: cancer & tumor microenvironment
- approach: experimental assay
- Citations
- 0
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