Nature CommunicationsDevelopmental BiologyPeer-reviewed journal article
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
Mírian RomittiiD, Adrien TourneuriD, Bárbara F. FonsecaiD, Gilles DoumontiD, Pierre GillotayiD, Xiao-Hui LiaoiD, Sema Elif EskiiD, Gaëtan Van SimaeysiD, Laura ChometteiD, Hélène LasolleiD, Olivier MonestieriD, Dominika Figini Kasprzyk, Vincent DetoursiD, Sumeet Pal SinghiD, Serge GoldmaniD, Samuel RefetoffiD, Sabine CostagliolaiD
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Abstract
The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the first transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone to athyreotic mice as a proof of concept for future therapeutic development.
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