Scientific ReportsNeurosciencePeer-reviewed journal article
Aging macaques bridge the translational gap in perivascular space biology
William A. LiguoreiD, Daniel L. Schwartz, Juan A. PiantinoiD, Avanthika Rajendran, Greg JenseniD, Joshua A. KarpfiD, Mykyta M. ChernoviD, Randall L. WoltjeriD, Steven G. Kohama, Lisa C. SilbertiD, Alison R. WeissiD
Abstract
The prevalence of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association between age and PVS burden, with an anatomical distribution paralleling that of humans. Preliminary ex vivo validation confirmed that the MRI-detected tubular structures correspond to perivascular spaces. These findings establish the rhesus macaque as a tractable model for understanding the role of perivascular dysfunction in age-related brain vulnerability.
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