Liver Disease Diagnosis and Treatment

The MASLD-causing E167K variant of TM6SF2 is degraded by the ubiquitin ligase RNF5

The paper identifies RNF5 as the ubiquitin ligase responsible for degrading the TM6SF2 E167K variant, a major risk factor for MASLD.

The hepatic sinusoid is a site of microvascular complications of hyperglycemia

This study identifies the hepatic sinusoid as a site of microvascular complications of hyperglycemia, showing that glucose-induced damage to liver sinusoidal endothelial cells (LSECs) through the hexosamine pathway and O-GlcNAcylation leads to capillarization and liver disease.

Nicotinamide N-methyltransferase couples inflammation and epigenetic remodelling to hepatic fibrosis

This study identifies NNMT as a regulator linking inflammation to epigenetic changes in liver fibrosis, showing its role in cytokine-induced transcriptional and fibrotic responses.

The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.