Regulation of Appetite and Obesity

This study identifies novel Ca2+ signaling mechanisms by which hypothalamic neurons in mice and humans rapidly respond to L-leucine, showing both activation and inhibition of specific neuron types.

This paper develops a predictive model for rats' calorie intake based on diet energy density and body weight, showing high accuracy in predicting intake patterns.

This study shows that protein-restricted rats develop a preference for protein-containing food and show increased palatability of protein compared to carbohydrate.

This study finds that genetic obesity, not diet-induced obesity, reduces orexin/hypocretin immunoreactivity in the lateral hypothalamus of mice.

This study identifies CeA Htr2a neurons as regulators of food consumption through positive valence mechanisms using in vivo activity manipulations and electrophysiology.

This study shows mTORC1 in AGRP neurons integrates food-related cues to control iBAT thermogenesis in mice, linking energy availability to adaptive energy expenditure.

The paper uses single-cell RNA sequencing to reveal heterogeneity in murine hypothalamic POMC neurons, identifying distinct subpopulations with different gene expression profiles and receptor expression.