Stroke Rehabilitation and Recovery

Whole-brain receptor markers and hub excitabilities determine acute and long-term outcomes in stroke

This study links receptor profiles and cortical excitability to acute and long-term stroke outcomes using patient-specific whole-brain models.

Post-stroke reorganization of gait-related functional muscle networks

This study examines how functional muscle networks reorganize after stroke and links these changes to motor impairment and gait dysfunction.

Quantifying the Effect of Trunk Postural Control on Reaching with Progressive Shoulder Abduction Loading in Hemiparetic Stroke

This study investigates how active trunk control affects reaching function in stroke patients under shoulder abduction loading, finding that trunk control reduces reaching distance but the flexion synergy is the main factor.

Sequence-Specific Reduction of Interlimb Accuracy Asymmetry Reveals Preserved Motor Learning Dynamics in Chronic Stroke: Insights from Lesion-Aware fMRI

This study identifies a behavioral phenotype of preserved motor sequence learning in chronic stroke using performance convergence and lesion-aware fMRI.

Bilateral Mechanoreception Discrimination based on Bihemispheric Somatosensory Response Patterns is Associated with Proprioception and Motor Function After Stroke

This study examines how bilateral somatosensory responses relate to proprioception and motor function after stroke, finding that decoder performance is strongly linked to motor outcomes.

Diaphragmatic EMG Uncovers Left-Right Diaphragmatic Imbalance After Ischemic Stroke with Implications for Motor Recovery

This study uses bilateral diaphragmatic electromyography to reveal left-right neuromuscular imbalance in mice after ischemic stroke, linking it to motor recovery.

Neuromuscular impairments alter energetic cost landscape curvature and stride speed variability in post-stroke locomotion

Normal Aging Limits Cortical Network Reorganization and Behavioral Recovery after Experimental Stroke

This study shows that aging impairs cortical network reorganization and behavioral recovery after stroke in mice, with young mice recovering despite persistent network degradation.

Extent of damage to descending output from cortex rather than to specific cortical regions drives the emergence of flexor synergy in non-human primates

This study shows that the severity of flexor synergy after stroke in non-human primates depends on the extent of corticofugal disruption, not specific cortical damage.

Reticulospinal Tract Hyperexcitability in the Upper Limb After Stroke is Associated with Motor Impairment and Not with Functional Compensation

This study confirms reticulospinal tract hyperexcitability after stroke is linked to worse motor outcomes, not functional compensation, in people with stroke.

Acute perilesional excitability explains long-term motor recovery after stroke

The paper uses computational whole-brain models to show that perilesional excitability predicts long-term motor recovery after stroke, but not acute impairment.

Cortical involvement in stroke survivors for balance maintenance

This study investigates how stroke affects cortical involvement in balance control by measuring corticokinematic coherence in stroke survivors and healthy controls.

The changing contributions of weakness and the flexor synergy to post-stroke arm function over time: A kinematic re-examination of Twitchell

This study re-examines Twitchell's 1951 findings on post-stroke arm function using modern kinematic analysis, showing that synergy intrusion and weakness evolve differently over time.

Neuronal integrity is altered in the ipsilesional hand sensory territory in late stroke

This study examines neuronal integrity in the ipsilesional hand sensory territory of chronic stroke patients using MR spectroscopy and finds reduced N-acetylaspartate levels correlating with cortical excitability.

Synergistic Effect of Valproate and Constraint Induced Movement Therapy on Functional Recovery Following Ischemic Stroke in Rats: Neuroplasticity and Corticosterone Associated Mechanisms

This study investigates the synergistic effect of valproate and constraint-induced movement therapy on functional recovery after ischemic stroke in rats, finding improved behavioral recovery and modulation of stress responses.

Contralesional activity reflects compensation, while brainstem detour pathways support skilled motor recovery after stroke

This study shows that contralesional brain activity compensates for stroke damage, while new brainstem pathways support motor recovery in trained mice.

Absence of cortical reorganization following an internal capsule stroke in rodents

This study compares cortical reorganization after motor cortex or internal capsule strokes in rats, finding delayed recovery and no long-term reorganization following internal capsule lesions.

Adaptive Multimodal Temporal Transformer for Bio Signal Driven Stroke Rehabilitation Prognosis

AMTT-Net improves stroke rehabilitation prognosis by dynamically fusing multi-modal bio-signals to predict recovery trajectories and responder likelihoods.

Rehabilitative Experience Interacts With FGF-2 to Facilitate Functional Improvement After Motor Cortex Injury

This study shows that combining complex housing with FGF-2 improves motor function more than either intervention alone in rats with motor cortex lesions.

Patterns of Structural Disconnection Driving Proprioceptive Deficits After Stroke

This study identifies white matter disconnection patterns linked to proprioceptive deficits after stroke using CLSM and kinematic assessments in chronic stroke survivors.

A global effort to benchmark predictive models and reveal mechanistic diversity in long-term stroke outcomes

This study benchmarks predictive models for long-term stroke outcomes using a global consortium, revealing mechanistic diversity and key predictors across motor, cognitive, and emotional domains.

Force variability is a potential biomarker of motor impairment in hemispheric stroke survivors

This study finds that force variability increases on the paretic side during specific motor tasks in stroke survivors, suggesting it could be a biomarker for motor impairment severity.

Combining Gamma Neuromodulation and Robotic Rehabilitation Restores Parvalbimin-mediated Gamma Function and Boosts Motor Recovery in Stroke Mice

This study combines gamma neuromodulation and robotic rehabilitation to restore gamma function and improve motor recovery in stroke mice.

Constraint Induced Movement Therapy Confers only a Transient Behavioral Benefit but Enduring Functional Circuit-Level Changes after Experimental TBI.

This study shows that CIMT provides temporary behavioral benefits but lasting changes in brain circuits after TBI in rats.

Harnessing early multimodal motor training to drive motor recovery and brain-wide structural reorganization after stroke

This study shows that early multimodal motor training after stroke improves motor function and causes widespread brain structural changes in rats.

Self-organizing recruitment of compensatory areas maximizes residual motor performance post-stroke

This study develops a neuro-musculoskeletal model to show how compensatory motor areas are recruited post-stroke to maximize residual motor performance through homeostatic and reinforcement learning processes.

EEG Responses to Upper Limb Pinprick Stimulation in Acute and Early Subacute Motor and Sensorimotor Stroke

This study uses EEG during pinprick stimulation to assess sensorimotor impairments in stroke patients, finding correlations between EEG oscillations and recovery outcomes.

Theoretical proposal for restoration of hand motor function utilizing plasticity of motor-cortical interhemispheric interaction

This paper proposes a rehabilitation strategy for hand motor recovery after stroke by leveraging interhemispheric plasticity through bilateral proprioceptive-motor coupling and movement training.

Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke

This study examines how corticospinal and corticoreticulospinal pathways relate to motor behaviors in chronic stroke patients, finding distinct contributions to motor control, strength, and muscle individuation in proximal and distal upper extremity segments.

Loss of finger control complexity and intrusion of flexor biases are dissociable in finger individuation impairment after stroke

This study examines finger individuation impairment after stroke, finding two dissociable factors: loss of control complexity and flexor bias intrusion.