Topic · Biochemistry · Medicine

Blood transfusion and management

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity

Monika Dzieciątkowska, Ariel M. Hay, Aaron Issaian, Gregory R. Keele, Shaun G. Bevers, Travis G. Nemkov, Julie A. Reisz, Mark D. Maslanka, Daniel Stephenson, Amy L Moore, Xutao Deng, Mars Stone, Kirk Charles Hansen, Steven H Kleinman, Philip J. Norris, , Angelo D’Alessandro

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

Haematologica · Sep 4, 2025Peer-reviewedBiochemistry

Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance

Sandy Peltier, Mickaël Marin, Monika Dzieciątkowska, Michaël Dussiot, Micaela Kalani Roy, Johanna Bruce, Louise Leblanc, Youcef Hadjou, Sonia Georgeault, Aurélie Fricot, Camille Roussel, Daniel Stephenson, Madeleine Casimir, Abdoulaye Sissoko, François Paye, , Pascal Amireault

This study identifies molecular and cellular changes in storage-induced senescent erythrocytes (SMEs) that lead to their clearance, showing altered metabolism, proteostasis, and membrane properties.

Journal of Clinical Investigation · Mar 11, 2025Peer-reviewedCell Biology