Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
7 papers
The paper develops a pump-leak model of epithelial transport to show how paracellular pathways and boundary conditions influence water and ion fluxes, with a focus on electroneutrality and osmotic gradients.
bioRxiv · Oct 27, 2026 · PreprintPhysiology
Tanvi Joshi, Kaisha Garvin, Matthew J. Flick, Montserrat Puigdelloses Vallcorba, Mehek Dedhia, Zhihong Chen, R Rodríguez Roche, Emir Radkevich, Susana Isabel Ramos, Nadejda M. Tsankova, Nhan L. Tran, Leland Hu, Katherine B. Peters, Alex J. Smith, Dieter Henrik Heiland, Dolores Hambardzumyan
This study shows that AQP4 regulates edema, maintains astrocyte differentiation, and limits immunosuppressive changes in glioblastoma.
bioRxiv · Oct 26, 2026 · PreprintCancer Biology
Michael J. Chandler, Julia W. Nalwalk, Preeti Dohare, Ariella D. Sprague, Alexandra L. Schober, Alexander A. Mongin
This study identifies LRRC8A/D-containing VRACs as the main pathway for swelling-activated taurine release in the brain but shows this pathway is not essential for systemic osmoregulation.
bioRxiv · Oct 23, 2026 · PreprintNeuroscience
The paper develops a general mathematical model of symport based on conformational transitions, showing it fits experimental data from multiple transporter families and reveals mechanistic principles.
bioRxiv · Oct 21, 2026 · PreprintPhysiology
Lucie Zerarga, Marie Himbert, Mélanie Try, Lydie Cheval, Pravina Muthan, Justine Billet, Nicolas Salaun, Clarice S. Groeneveld, Gaëlle Brideau, Sylvie Demaretz, Rémi Toutain, Luciana Morla, Emmanuelle Vidal‐Petiot, Martin Flamant, François Vrtovsnik, , Nahid Tabibzadeh
This study identifies Gdf15 as a key mediator of lithium-induced collecting duct dysfunction and remodeling, linking spatial stress responses to functional and structural kidney injury.
bioRxiv · Oct 19, 2026 · PreprintPharmacology & Toxicology
This study investigates aquaporin (Aqp) function and evolution in reef-building corals, finding that Aqp4L proteins are water-selective while Glp proteins transport both water and solutes, with some showing unexpected solute permeability.
bioRxiv · Oct 14, 2026 · PreprintEvolutionary Biology
Elías Vera-Sigüenza, Ramin Nashebi
The paper develops a dynamic model of salivary fluid secretion to show that chloride availability, not just monovalent cation transport, is critical for Ae4-dependent secretion.
bioRxiv · Oct 12, 2026 · PreprintCell Biology