Forensic and Genetic Research

This paper introduces GhostBuster, a method to detect unsampled admixture events in human history using genome-wide genealogies, revealing multiple back-to-Africa migrations and deep ancestral lineages.

This paper develops a method to infer hominin demographic history using two-locus statistics from single unphased genomes, revealing two episodes of gene flow and population structure in ancient Eurasian AMH.

The paper analyzes shotgun genomes from the medieval Hungarian elite, revealing homogenization through admixture and identifying a previously unrecognized Conquest-period stratum.

This study analyzes ancient DNA from a rural English cemetery to explore genetic continuity and change following the Norman Conquest, finding no genome-wide discontinuity.

This study sequenced ancient and modern genomes from the Ryukyu Archipelago to show genetic differentiation between Ryukyu Jomon and Hondo populations, with admixture occurring around 1,000 YBP.

ARGMix uses a graph transformer to infer local ancestry from ancient DNA, showing continuity between Otzi the Iceman and present-day Europeans.

EGP1K sequenced 1,024 Egyptians to characterize genetic diversity and population structure, revealing distinct ancestry components and highlighting issues with European-derived polygenic risk score thresholds.

This study uses genetic analysis of skeletal remains from Columbus' descendants to provide indirect evidence about his origins and place of birth.

The paper identifies convergent natural selection in East and West Eurasia for immune and cardiometabolic traits, but finds distinct patterns for light skin color.

The paper analyzes DNA and metagenomic data from the 1978 Shroud of Turin samples, revealing human mtDNA lineages, microbial communities, and contaminants, while radiocarbon dating indicates repair events in the 16th and 17th centuries.

This study analyzes ancient genomes from the Altai region to show genetic continuity and shifts between the 4th and 12th centuries, including the spread of East Asian ancestry and a unique lineage with Ancient North Eurasian ancestry.

PCLAI infers continuous genetic ancestry across the genome using a point cloud representation, enabling time-stratified geographic insights from ancient samples.

The paper uses ancient DNA data from the eastern Colombian Andes to show that subsistence changes involving maize occurred without population replacement, followed by a major genetic turnover linked to the Herrera culture.

The paper presents a comprehensive genomic atlas of Indian populations, identifying novel variants and highlighting genetic diversity and pharmacogenomic implications.

This paper confirms the genealogical relationship between Otto I and Heinrich II through ancient DNA analysis and whole-genome sequencing.

This paper evaluates neural network-based methods for local ancestry inference in challenging admixture scenarios and finds they perform best with specialized preprocessing.

This study applies nanopore sequencing to ancient DNA from the Early Jomon period, demonstrating its ability to generate genome-wide data and enable rapid, on-site paleogenomic analysis.

The paper develops a method to infer directional migration rates from ancient DNA data using time-dependent F2 statistics, revealing an ancient pan-European migration network.

The paper shows that cultural norms and mobility patterns in hunter-gatherer societies influence genetic diversity and reduce homozygosity, preserving fitness.

The paper proposes a quantitative model explaining RhD-negative allele frequency peaks in Ibero-Berber populations through synergistic selection and admixture.

This paper introduces a framework using STR variations for high-resolution population structure inference, showing STRs provide finer resolution than SNPs.

This study evaluates kinship inference in sedimentary ancient DNA by simulating data and applying a heterozygosity-based test to identify multi-contributor samples.

The paper introduces mtDNA-Network, a tool for analyzing mitochondrial variants in admixed Brazilian populations with complex diseases.

The paper introduces the Tweap protocol, an optimized target enrichment method for ancient DNA, which reduces costs and increases SNP recovery compared to the Twist protocol.

The paper analyzes whole-exome sequencing data from 13 tribal groups in Odisha, India, identifying genetic structure, rare variants, and clinically relevant pathogenic variants.

This study identifies genomic signals of selection in Asian populations linked to immunity, diet, and subsistence strategies, revealing complex interactions between cultural practices and natural selection.

This study uses ancient DNA to identify global patterns of natural selection across 7244 individuals from five regions, finding shared and region-specific adaptive signals.

The paper develops a minimally invasive workflow to recover biological signatures from Renaissance-era artifacts, revealing microbial biomes and Y-chromosome markers linked to historical handling and conservation.