Dermatology and Skin Diseases

Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

This study demonstrates that mRNAs can be non-invasively collected from skin surface lipids and used to analyze gene expression in skin diseases like atopic dermatitis.

Scratching bouts are modeled as Bernoulli trials until successful itch-extinguishing in mice

The paper models scratching bouts in mice as Bernoulli trials, finding that the distribution of itch episodes follows a geometric distribution with success probability 0.5 in healthy mice.

Epigenetic and Transcriptional Dysregulation in CD4+ T cells of Patients with Atopic Dermatitis

This study identifies epigenetic and transcriptional dysregulation in CD4+ T cells of atopic dermatitis patients, linking genetic risk variants to altered chromatin accessibility and NFKB1 binding.

Determinants of Murine Skin Microbiota Composition in Homeostasis and Wound Healing

This study shows that host genetics significantly influences murine skin microbiota composition during homeostasis and wound healing, with genetic background explaining most variation in microbiota and healing speed.

Triangulating molecular evidence to prioritise candidate causal genes at established atopic dermatitis loci

This paper prioritises candidate causal genes at 25 atopic dermatitis GWAS loci using a novel pipeline called ADGAPP, identifying both known and novel candidates.

Identification of theTMEM232 gene associated with atopic dermatitis through targeted capture sequencing

This study identifies TMEM232 as a gene associated with atopic dermatitis through haplotype analysis and targeted capture sequencing.

Explainable AI reveals changes in skin microbiome compositionlinked to phenotypic differences

The paper develops an explainable AI approach to predict skin-related phenotypes from leg skin microbiome data and identifies microbial composition changes linked to these traits.

Molecular signature of pruriceptive MrgprA3+ neurons

The paper identifies the molecular signature of MrgprA3+ neurons and their unique response to dermatitis, revealing novel markers and mechanisms of itch sensation.

Molecule guided laser ablation as a novel therapeutic strategy to control itch.

This paper develops a molecule-guided laser ablation strategy to control itch by targeting itch-sensing neurons in mouse models of skin diseases.

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

This paper develops a cost-effective and efficient sequencing protocol for the filaggrin gene to detect disease-associated variants across diverse populations.