Temporomandibular Joint Disorders

Multiscale Biomechanical and Electrophysiological Modeling of Nociceptive Activation in Musculoskeletal Joint Disorders: Insights from the Temporomandibular Joint

This study develops a multiscale computational model linking TMJ structural changes to nociceptive activation by integrating biomechanics, neural morphology, and electrophysiology.

Innervation of Retrodiscal Tissues in Patients with Temporomandibular Joint Disorder

This study examines sensory and sympathetic nerve profiles in retrodiscal tissues of TMJD patients, finding reduced sensory nerve density in condylar hyperplasia compared to other subtypes.

Why detailed modelling matters in the pre-clinical evaluation of temporomandibular joint implants

This study evaluates how different levels of detail in finite element models affect stress-strain predictions in TMJ implants, finding that simplified models can be used for preliminary design but detailed models are needed for final evaluation.

Modeling Masticatory Myalgia to Headache-like Referred Pain Triggers Local Gene Plasticity at Referred Pain Sites

This study models referred pain in mice by stimulating masticatory muscles and finds that TM stimulation induces longer-lasting headache-like behavior and gene plasticity in referred sites.

FSP1 stem/progenitor cells are essential for TMJ growth and homeostasis

This study identifies FSP1-expressing cells as essential stem/progenitor cells in the TMJ condyle, showing their role in growth, homeostasis, and cartilage maintenance through Wnt signaling regulation.

Elucidation of neuronal activity in mouse models of TMJ injury by in vivo GCaMP Ca2+ imaging of intact trigeminal ganglion neurons

This study uses in vivo GCaMP3 Ca2+ imaging to analyze neuronal activity in trigeminal ganglia of TMJ injury models, finding increased responsiveness to stimuli and the effectiveness of CGRP antagonists in reducing hypersensitivity.

Forced mouth opening induces post-traumatic hyperalgesia and associated peripheral sensitization after temporomandibular joints injury in mice

This study investigates how forced mouth opening induces hyperalgesia and peripheral sensitization in mice following temporomandibular joint injury.

Association of inflammation and tissue damage inducedbiological processes in masseter muscle with the resolution of chronic myalgia

This study investigates how inflammation and tissue damage in masseter muscle relate to the resolution of chronic myalgia using CFA and collagenase-induced models.

Effect of changing the direction of the force vector of the mandible in relation to the skull base: study in rabbits

This study evaluates the adaptive capacity of rabbit temporomandibular joints to unilateral changes in mandibular force vector direction, showing significant histomorphometric differences between test and control groups.