Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
2 papers
Xiangzhe Kong, Rui Jiao, Haowei Lin, Ruihan Guo, Wenbing Huang, Wei‐Ying Ma, Zihua Wang, Yang Liu, Jianzhu Ma
PepMimic, an all-atom latent diffusion model guided by a contrastive interface encoder, designs peptides mimicking known binders; 8% of tested peptides across five targets reached 10^-8M KD.
Nature Biomedical Engineering · Oct 1, 2025Peer-reviewedBiochemistry✦ In-depth digest
Karsten D. Householder, Xinyu Xiang, Kevin M. Jude, Arthur Deng, Matthias Obenaus, Yang Zhao, Steven C. Wilson, Xiaojing Tina Chen, Nan Wang, K. Christopher García
A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.
Science · Jul 24, 2025Peer-reviewedImmunology✦ In-depth digest