Immune Cell Function and Interaction

Disease-associated NK-cell state remodeling reveals transcriptional profiles predictive of clinical phenotypes

The paper establishes the Human NK-cell Atlas and identifies disease-specific NK-cell state remodeling, developing a model to predict clinical phenotypes.

Technology solutions for immune loci: integrated high-resolution KIR genotyping reveals allelic, structural, and KIR-HLA diversity across 24 human populations

This paper develops a high-resolution KIR genotyping system that accurately identifies allelic, structural, and KIR-HLA diversity across 24 human populations.

Signal Associa: hot tumors elicit field-spanning NK cell coordination linked to their recruitment

Signal Associa identifies coupling regimes in NK cell dynamics across tumor microenvironments, showing hot tumors elicit more integrated NK cell networks.

Selective granzyme B replenishment dominates the molecular switch for sustained cytotoxicity in effector CD8+ T lymphocytes

This study shows that human CTLs sustain cytotoxicity by selectively replenishing granzyme B through de novo synthesis, maintaining its activity and supporting prolonged killing.

Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

This study identifies an allosteric disulfide bond in KIR2DL4 that regulates HLA-G binding and endocytosis, influencing NK cell function during pregnancy.

Self-reactive human CD8⁺ T cells restricted by HLA-E mediate immunoregulatory and antiviral functions

The paper identifies E-sensors, HLA-E-restricted CD8+ T cells that recognize increased self-VL9/HLA-E, mediating immunoregulation and antiviral responses in HIV control.

Worldwide diversity and geographic structure of killer-cell immunoglobulin-like receptor (KIR) gene content

The paper analyzes global KIR gene diversity, finding strong regional differentiation and a decline in diversity with distance from East Africa in the Old World.