A Measurable Systemic Immune Phenotype Links Circulating Myeloid Dysfunction to Tumour Spatial Organization in Gastroesophageal Adenocarcinoma
Iqraa Dhoparee‐Doomah, Yichen Li, Manal Al Dow, Shayan Hajhashemi, Ariane Brassard, Nissim Benizri, Sabrina Leo, Katy Milne, Ming Zi Xu, Qian Qiu, Brad H. Nelson, Pierre-Olivier Fiset, Betty Giannias, France Bourdeau, Jonathan Spicer, , Jonathan Cools‐Lartigue
This study links circulating myeloid dysfunction, measured by cNLR, to tumour spatial organization in GEA through multiscale analyses of immune function, single-cell transcriptomics, and spatial myeloid organization.
bioRxiv · Sep 18, 2026 · PreprintCancer Biology