Genetic and Kidney Cyst Diseases

Identification of candidate ciliary microtubule-associated proteins using CEP41 proximity labeling

The paper identifies novel ciliary microtubule-associated proteins using BioID proximity labeling and proteomics, expanding the known repertoire of ciliary MAPs.

Targeting SUFU-mediated GLI activity alleviates ciliopathic phenotypes

This study shows that modulating SUFU-GLI interactions rescues ciliopathic phenotypes in mice by restoring GLI transcriptional activity without requiring ciliary processing.

Odad1 is Required for Deployment of Axonemal Outer Arm Dyneins and Embryonic Left-Right Patterning

This study shows ODAD1 is essential for ODA-DC assembly in 9+0 and 9+2 cilia, causing left-right patterning and ciliary motility defects in ciliopathy.

Structural modelling predicts that fibrocystin destabilisation is a pathogenic cause of ARPKD

The paper uses structural modeling to show that fibrocystin destabilization due to PKHD1 missense mutations is a key pathogenic mechanism in ARPKD, suggesting stabilization as a therapeutic target.

CiliaBuilder2: a flexible ChimeraX bundle to visualize cilia and centriole structures in 3D

CiliaBuilder2 enables flexible 3D visualization of ciliary structures from diverse data types in ChimeraX.

Heterogeneity in cilia patterning enables multiple flow functions in Paramecium

Paramecium tetraurelia partitions its ciliary array into a dense, fast-beating domain anterior to the oral apparatus that drives feeding flows and a sparser, slower domain that drives swimming.

An Analog-Sensitive Tau Tubulin Kinase 2 Enables Acute Chemical-Genetic Control of Primary Cilia

This paper introduces an analog-sensitive TTBK2 variant to enable precise control of TTBK2 kinase activity, revealing dynamics of ciliary processes in hTERT-RPE1 cells.

Primary cilia facilitate GPCR neurotransmission through the canonical cAMP cascade

The paper shows that primary cilia in striatal neurons facilitate dopamine receptor-initiated cAMP/PKA signaling beyond the cilium, challenging the view that ciliary neurotransmission is restricted to non-canonical pathways.