Ocular Infections and Treatments

Pseudomonas aeruginosa impairs mitochondrial function and metabolism during infection of corneal epithelial cells

This study shows that Pseudomonas aeruginosa infection causes mitochondrial fission and metabolic changes in corneal epithelial cells, which are reversed after antibiotic treatment.

Topical Formulation of Repurposed FDA-Approved Compounds Inhibits Pseudomonas aeruginosa ExoU and Improves Corneal Infection Outcomes

This study identifies FDA-approved compounds that inhibit ExoU, a virulence factor in Pseudomonas aeruginosa, and shows their efficacy in reducing corneal infection severity in multiple models.

Pseudomonas aeruginosa Exotoxin A is not essential for corneal disease severity or bacterial survival

The paper shows that Exotoxin A is not essential for bacterial survival or corneal disease severity in P. aeruginosa keratitis in mice.

Prior contact lens wear reduces susceptibility of the superficially-injured cornea to bacterial adhesion

The paper shows that prior contact lens wear reduces bacterial adhesion to superficially-injured corneas in mice, correlating with increased Lyz2+ immune cells, but with differing effects on commensal and pathogen behavior.

Modeling Rotational Fluoroquinolone Therapy as a Novel Treatment for Ophthalmic MRSA Infections

The paper evaluates rotational fluoroquinolone therapy for ophthalmic MRSA infections, showing it improves bacterial clearance compared to monotherapy by leveraging resistance profiles and pharmacokinetics.

Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis

This study identifies HAdV-D-specific mechanisms of HMGB1 secretion and subepithelial infiltrate formation in EKC by infected corneal epithelial cells.

Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model

This paper introduces an ex vivo porcine corneal infection model using plumbing rings to improve antimicrobial application and assess its efficacy against Pseudomonas aeruginosa.

New Insight Into the Neuroimmune Interplay In Pseudomonas aeruginosa Keratitis

This study investigates the role of miR-183C in corneal sensory nerves during Pseudomonas aeruginosa keratitis, showing its impact on nerve degeneration and immune cell dynamics.

Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria

This study shows that contact lens wear changes corneal epithelium and bacterial gene expression responses to Pseudomonas aeruginosa, promoting bacterial virulence and adaptation.

The mammalian Ire1 inhibitor, 4μ8C, exhibits broad anti-Aspergillus activity in vitro and in a treatment model of fungal keratitis.

This paper investigates the antifungal properties of 4μ8C, an Ire1 inhibitor, showing strong activity against Aspergillus fumigatus in vitro and in a fungal keratitis treatment model.

Metagenomic DNA sequencing for the diagnosis of intraocular infections

This study compares metagenomic DNA sequencing with pathogen-directed PCR for diagnosing intraocular infections, finding DNA-seq detects more pathogens and identifies drug resistance mutations.