Respiratory and Cough-Related Research

Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough

This study shows that Mycobacterium tuberculosis produces phenolic glycolipid (PGL) that activates neurons and induces cough by triggering ATP-mediated P2X3 signaling.

Sneezing in response to bright light exposure: A case study in a photic sneezer

This study characterizes photic sneezing in response to natural and artificial light stimuli and finds that sudden increases in illuminance trigger sneezing, though artificial stimuli failed to induce it.

A brainstem circuit controls cough-like airway defensive behaviors in mice

This study identifies a brainstem circuit in mice that controls cough-like airway defensive behaviors through neural activity in the caudal spinal trigeminal nucleus.

Genomics of chronic cough unravels neurological pathways

This study identifies seven novel genetic loci associated with chronic dry cough and ACEi-induced cough, implicating neurological genes and highlighting potential therapeutic targets.

Genome-wide association study of ACE inhibitor-induced cough implicates neuropeptides and shows genetic overlap with chronic dry cough

This study identifies genetic associations with ACE inhibitor-induced cough and finds shared genetic factors with chronic dry cough.

Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker

This paper develops a novel cationic compound, BW-031, that effectively inhibits cough by targeting large pore-expressing airway sensory neurons through aerosolized delivery.