Amoebic Infections and Treatments

Peptidyl Protease Inhibitors Block ERM-BP Function and Suppress Entamoeba Encystation

This study identifies peptidyl protease inhibitors PFMK and EBLL as compounds that block ERM-BP function and suppress Entamoeba encystation.

Intrinsic protein disorder reveals divergent signaling architectures and lifestyle adaptation in Entamoeba species

This study compares intrinsic protein disorder across Entamoeba species and other parasites, finding differences in disorder distribution linked to lifestyle and pathogenicity.

Screening of Potential Vaccine Candidate and Sera Based Diagnostic Markers from N-linked Surface Glycoproteins of Entamoeba histolytica

This study identifies immunogenic surface glycoproteins from Entamoeba histolytica that show differential antibody responses in patients with amoebic colitis and liver abscesses, suggesting their potential as diagnostic markers and vaccine candidates.

Chromosome organization of Entamoeba histolytica and Entamoeba dispar

The paper assembles and analyzes the genomes of Entamoeba histolytica and Entamoeba dispar, revealing their chromosome structures and ploidy levels.

Distinct temporal patterns of liver immune responses to pathogenic and non-pathogenic Entamoeba histolytica clones

This study compares immune responses to pathogenic and non-pathogenic E. histolytica clones in mice, finding distinct temporal transcriptomic profiles linked to disease severity.

Human cell F-actin density differentially influences trogocytosis and phagocytosis by Entamoeba histolytica

This study investigates how human cell F-actin organization affects trogocytosis and phagocytosis by E. histolytica, finding differential impacts on these processes.

Pleckstrin homology domain-containing serine/threonine kinase plays a crucial role in the survival and phagocytosis of Entamoeba histolytica.

This study identifies EhPHDK as a critical kinase for Entamoeba histolytica survival, phagocytosis, and cytoskeletal dynamics, with potential as a therapeutic target.

The gut microbiota-derived metabolite indole regulates cytoskeletal functions and virulence in Entamoeba histolytica

This study shows that indole, a gut microbiota-derived metabolite, is initially toxic to Entamoeba histolytica but adaptation leads to increased virulence and stress resistance.

Entamoeba histolytica Gal/GalNAc lectin intermediate subunit promotes inflammation and epithelial damage in intestinal amebiasis through its C3 region.

This study identifies the role of E. histolytica Igl in promoting inflammation and epithelial damage in intestinal amebiasis through its C3 region via TLR4/MyD88/NF-κB signaling.