Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy
Alyssa Baccarella, Yusen Zhou, Tatiana A. Karakasheva, Ravi Gautam, Megha Lal, Jarad Beers, Zoe Mrozek, Ann Semeao, Leena Mirchandani, Ryugo Teranishi, Takefumi Itami, Kanak Kennedy, Mark Mahon, Ezuka Ogbolu, Judith R. Kelsen, , Melanie A. Ruffner
The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.
bioRxiv · Oct 30, 2026 · PreprintCell Biology