Author

Megha Lal

Children's Hospital of PhiladelphiaORCID 0000-0002-9235-7255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Jarad BeersiD· 2 shared Melanie A. RuffneriD· 2 shared Ravi GautamiD· 2 shared Zoe Mrozek· 2 shared Alyssa BaccarellaiD· 1 shared Amanda B. MuiriD· 1 shared Ann Semeao· 1 shared Ezuka Ogbolu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Jarad BeersORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy

Alyssa Baccarella, Yusen Zhou, Tatiana A. Karakasheva, Ravi Gautam, Megha Lal, Jarad Beers, Zoe Mrozek, Ann Semeao, Leena Mirchandani, Ryugo Teranishi, Takefumi Itami, Kanak Kennedy, Mark Mahon, Ezuka Ogbolu, Judith R. Kelsen, , Melanie A. Ruffner

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

bioRxiv · Oct 30, 2026 · PreprintCell Biology

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils

Ravi Gautam, Megha Lal, Margaret C. Carroll, Zoe Mrozek, Tina Trachsel, Jarad Beers, Melanie A. Ruffner

This study shows that omeprazole modulates esophageal epithelial barrier function and reduces eosinophil activation in an IL-13-induced model of eosinophilic esophagitis.

Pediatric Allergy and Immunology · Feb 27, 2026Peer-reviewedImmunology