Drug-Induced Ocular Toxicity

Using Patient iPSC-derived Retinal Pigment Epithelial Cells to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy

The paper compares MEK inhibitor effects on iPSC-derived RPE cells from patients with and without MEKAR, finding differential gene expression and phagocytic activity.

Retinal Pigment Epithelium Injury in Pentosan Polysulfate Exposure: Morphologic Changes, Phagocytic Deficits, and Mitochondrial Dysfunction

This study investigates the effects of pentosan polysulfate on retinal pigment epithelium cells, finding mitochondrial dysfunction and impaired phagocytosis.

Modeling MEK inhibitor-Associated Retinopathy in vitro using human induced pluripotent stem cell-derived retinal pigment epithelial cells

This study investigates the effects of MEK inhibitor selumetinib on hiPSC-derived RPE cells, finding increased internalization of rod outer segments and decreased aquaporin 1 expression, suggesting a mechanism for MEKAR.

Retinal gene and pathway modulation by benzathine penicillin: A potential link to Extensive Macular Atrophy with Pseudodrusen (EMAP) and neurodegeneration.

This study identifies BP-modulated genes in retinal tissues linked to EMAP and neurodegeneration, highlighting inflammation and oxidative stress pathways.