Apelin-related biomedical research

Early apelin receptor activation attenuates elastase-induced emphysema and preserves endothelial apelin receptor signaling in mice

This study shows early apelin receptor activation reduces emphysema in mice by limiting inflammation and airspace enlargement, but has no effect after disease onset.

Apelin-13 in the paraventricular nucleus protects myocardium from ischemia via V1a receptor of the paraventricular nucleus and GABAA receptor γ2 of the nucleus tractus solitarii in rats

This study shows that apelin-13 overexpression in the paraventricular nucleus improves cardiac function in MI and I/R rats via V1a receptors and GABAA receptor γ2 in the nucleus tractus solitarii.

White Tea Mitigates Obesity-Related Metabolic Disorders Through Apelin and Insulin Modulation in Rats

This study shows white tea reduces weight gain and cholesterol in obese rats by modulating apelin and insulin levels.

Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis

The paper shows that leukemia cells secrete apelin, which promotes clonal expansion of niche endothelial cells and drives leukemogenesis in zebrafish.