Nutrition, Genetics, and Disease

Biobank-scale survey of gene-diet interactions informs precision nutrition polygenic scores

The paper assesses gene-diet interactions in UK Biobank data to derive polygenic scores that associate with cardiometabolic outcomes and clinical conditions like gout.

Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial

This study evaluates if weight loss from a dietary intervention varies by genetic predisposition to higher BMI, finding no significant interaction between polygenic scores and intervention effectiveness.

Multi-Omics and AI-/ML-Driven Integration of Nutrition and Metabolism in Cancer: A Systematic Review, Meta-Analysis, and Translational Algorithm

This paper reviews and analyzes how multi-omics and AI/ML approaches integrate nutrition and metabolism in cancer, showing strong diagnostic and predictive capabilities and proposing a clinical algorithm for low-resource settings.

Precision pharmacological reversal of genotype-specific diet-induced metabolic syndrome in mice informed by transcriptional regulation

The paper uses mouse models to study diet-induced metabolic syndrome, identifies strain-specific transcriptional and epigenomic changes, and tests genotype-targeted pharmacological interventions.

The impact of a reduced calorie, macronutrient diet change on Caucasian males in relation to genotypes associated with obesity, increased BMI and dietary response.

This study examines how a reduced calorie, macronutrient diet affects Caucasian males with specific obesity-related genotypes, identifying genetic factors influencing dietary response.