Nutrition, Genetics, and Disease

Diet-responsive proteogenomic effects following short-term restriction of animal products in humans

The paper identifies diet-responsive cis-pQTLs in humans following short-term animal product restriction, revealing diet-dependent genetic regulation of proteins involved in metabolism and immunity.

Biobank-scale survey of gene-diet interactions informs precision nutrition polygenic scores

The paper assesses gene-diet interactions in UK Biobank data to derive polygenic scores that associate with cardiometabolic outcomes and clinical conditions like gout.

Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial

This study evaluates if weight loss from a dietary intervention varies by genetic predisposition to higher BMI, finding no significant interaction between polygenic scores and intervention effectiveness.

Multi-Omics and AI-/ML-Driven Integration of Nutrition and Metabolism in Cancer: A Systematic Review, Meta-Analysis, and Translational Algorithm

This paper reviews and analyzes how multi-omics and AI/ML approaches integrate nutrition and metabolism in cancer, showing strong diagnostic and predictive capabilities and proposing a clinical algorithm for low-resource settings.

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

This study examines how a lifestyle intervention affects the blood transcriptomic and metabolomic responses to a nutrient challenge in elderly individuals.

Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity, and Cardiovascular Disease

The paper examines how ancestry-specific polygenic risk scores interact with diet and physical activity to influence ASCVD risk in European Americans and African Americans.

Data-driven precision nutrition improves clinical outcomes and risk scores for IBS, depression, anxiety, and T2D

This paper presents a data-driven precision nutrition platform that improves clinical outcomes and risk scores for IBS, depression, anxiety, and T2D through personalized dietary recommendations based on gut microbiome and host gene expression data.

Precision pharmacological reversal of genotype-specific diet-induced metabolic syndrome in mice informed by transcriptional regulation

The paper uses mouse models to study diet-induced metabolic syndrome, identifies strain-specific transcriptional and epigenomic changes, and tests genotype-targeted pharmacological interventions.

Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits

The paper identifies a gene-diet interaction modifying the association between macronutrient intake and glycemic traits, highlighting challenges in detecting such interactions due to measurement error and sample size.

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

This study uses Mendelian randomization to identify 417 potential causal links between dietary patterns and blood metabolites, including novel associations and replication of known ones.

Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on Hemoglobin A1c

The paper identifies five novel gene-diet interaction effects on HbA1c using UK Biobank data, highlighting interactions with dietary patterns and traits.

A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative

The paper develops a gene-diet interaction score to predict dietary fat response for cardiometabolic risk factors using the Women's Health Initiative cohort.

The impact of a reduced calorie, macronutrient diet change on Caucasian males in relation to genotypes associated with obesity, increased BMI and dietary response.

This study examines how a reduced calorie, macronutrient diet affects Caucasian males with specific obesity-related genotypes, identifying genetic factors influencing dietary response.

Effect of obesity-linked FTO rs9939609 variant on physical activity and dietary patterns in physically active men and women

The paper examines physical activity and dietary patterns in individuals with different FTO rs9939609 variants, finding no differences in obesity-related metrics but higher activity and cognitive restraint in risk allele carriers.