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The paper develops an in silico framework to model human kidney haemodynamics using HiP-CT data, showing vascular geometry and resistance scaling influence kidney function.

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

This paper introduces a kernel-based style transfer mapping method for cross-subject biosignal classification, showing improved accuracy over linear methods.

This paper develops and evaluates a bioabsorbable PLA middle ear ventilation tube, showing good biocompatibility and no adverse effects on hearing in a guinea pig model.

This paper develops a fluid model to evaluate 96-well mixing protocols and surveys existing practices, finding that three cycles are often insufficient for uniform mixing.

MusTer improves single-cell sequencing by reducing doublets, enhancing signal-to-noise ratio, and improving cell clustering in maize leaf ATAC-seq.

The paper develops a microphysiological model of lung fibrosis to study myofibroblast-vascular interactions, finding that myofibroblasts reduce angiogenesis and vasculogenesis through TGF-β1 and reduced VEGF.

The paper introduces a high-throughput culturing platform with real-time metabolic profiling to study cellular metabolism and mitochondrial dysfunction.

This study shows that culturing primary melanocytes on nanoparticle substrates reduces focal adhesions and increases stemness gene expression while decreasing differentiation markers.

This paper improves anaerobic digestion models by integrating metaproteomics data to better represent microbial functions and dynamics in a two-step digester system.

This study identifies a combination of adjuvants that enhance the immunogenicity of naked mRNA vaccines delivered by jet-injection, achieving protection against SARS-CoV-2 and influenza with reduced reactogenicity.

This paper develops an iterative epitope-expansion strategy to design IgE-binding miniproteins targeting the FcεRI interface, improving affinity and validating structural models through experimental testing.

This study develops a photoresponsive synthetic basement membrane to investigate injury and repair processes in epithelial cells, finding that critical injury sizes lead to dysregulated re-epithelialization.

This paper demonstrates that DNA nanocages delivering aspirin reduce excitotoxicity and promote neuroprotection in zebrafish models of ischemic stroke.

This paper presents an automated microfluidic platform for generating large, precisely-defined lipid nanoparticle libraries and evaluates their physicochemical and transfection properties.

CellTrap enables long-term, single-cell analysis of immune-cancer interactions by controlling effector-to-target ratios, showing enhanced immune activity with higher ratios.

This paper develops a genetically engineered EV platform that increases yield and eliminates toxicity, enabling safe high-dose systemic delivery.

This paper develops a microfluidic device called LARLM for producing uniform lipid nanoparticles (LNPs) with high productivity and demonstrates improved bioavailability of loaded drugs in vitro.

This paper demonstrates that using affinity cocktails of antibody-radioconjugates improves tumor irradiation by combining high- and low-affinity variants to target different tumor regions, leading to better treatment outcomes.

This study incorporates the AcChiA chitinase protein into AcMNPV occlusion bodies, enhancing oral infectivity and larval mortality in bioassays.