Discover, rate, and discuss biology preprints.

The paper introduces an acoustic pH sensor called pHonon for deep tissue imaging of cellular acidification using nonlinear ultrasound.

BRAT is a tool for high-content microscopy screening of microvascular networks, offering fast and accurate analysis of vascular images.

This paper develops a holistic human movement model and a human-aware control algorithm for robot interaction, showing improved prediction of user behavior and reduced neuromuscular effort in simulations.

This study uses label-free optical imaging to compare metabolic changes in macrophages after cryopreservation versus fresh isolation, finding significant metabolic alterations post-cryopreservation.

The paper introduces an imaging platform for long-term monitoring of multi-cellular assemblies in an incubator, demonstrating its use with hiPSCs and yeast cells.

This study demonstrates ectoine production from biogas by marine methanotroph-microalgae cultures, showing that osmotic stress enhances ectoine accumulation while high NaCl inhibits it.

This study introduces DECODE, a high-throughput method for identifying epitopes at single amino acid resolution, demonstrating its utility in antibody-based research and disease modeling.

This paper introduces a bioengineered composite mesh for pelvic floor disorders, showing good biocompatibility and mechanical properties but requiring further refinement to reduce inflammation.

This study uses automated cell dispensing to create 3D cancer cell models for high throughput screening, showing minimal impact on cell behavior and improved efficiency.

This paper develops a photo-responsive protein system to dynamically control microtubule superstructures using light.

This paper develops a method to precisely place colloidal quantum emitters on photonic chips using DNA origami, enabling nanometer-scale integration and single-photon emission.

This study shows that introgression of a wild genetic background into Wolbachia-infected Aedes albopictus males restores their fitness and mating competitiveness, enhancing the effectiveness of the Incompatible Insect Technique.

This paper develops a microfluidic co-culture system that enables the reproducible formation of vascularised adipose tissue from immortalised cells, showing that vascular networks significantly enhance adipocyte differentiation.

This paper develops a scalable method to create recyclable and tougher biocomposite TPUs by embedding spore-based living fillers, showing improved toughness and recyclability.

This study characterizes microbubble cavitation in theranostic ultrasound-mediated BBB opening and gene delivery, finding that longer pulses and specific microbubble sizes enhance cavitation and transgene expression.

This study measures NAD+ T1 and T2 relaxation times in human brain using 7 T 1H MRS and quantifies the uncertainty propagation in NAD+ concentration.

This study evaluates the failure of artificial tendons attached with suture anchors in rabbits, finding suture breakage as the primary failure mode, independent of implant timing or suture size.

This study shows that macromolecular diABZI conjugates activate STING in vitro and in vivo, with similar potency to small molecule agonists, suggesting new strategies for STING agonist delivery.

This paper introduces JAM, a generative system for de novo antibody design that achieves high-affinity, developable antibodies against various targets without experimental optimization.

This paper introduces Bayesian survival analysis methods with beta process priors for variable selection in high-dimensional data, showing improved performance over existing techniques.