Discover, rate, and discuss biology preprints.

This paper applies topological principles to fingerprint patterns, showing they follow a nematic field model with topological constraints.

This paper introduces a contactless micro-elastography method using oscillating microbubbles to measure single-cell mechanical properties rapidly and label-free.

This study examines how anesthetics affect erythrocyte aggregation and viscoelasticity in normal and glycated human red blood cells, showing differential effects between the two groups.

This paper investigates how aducanumab binds to Aβ1-42 fibrils, showing it preserves the fibril core structure while altering N-terminal dynamics and reducing secondary nucleation.

This study uses a computational model to show that in tumours, oxygen and drug concentration overlap is reduced compared to healthy tissue, affecting drug efficacy.

The paper integrates the assembly of 21 macromolecular complexes into a whole-cell kinetic model of JCVI-syn3A, improving efficiency and consistency with experimental data.

This study shows glycopolymers stabilize protein folding and interactions through enthalpic interactions, challenging simple volume exclusion models of crowding.

The paper analyzes the spread of H5N1 avian influenza in North America, identifying seasonal patterns and a phase transition linked to mammalian cases and regional viral amplification.

This study demonstrates photothermal transport of nanoparticles through the vitreous humor using pulsed-lasers and indocyanine green, enabling guided drug delivery to the retina.

The paper models DNA replication in yeast to show replication-dependent spatial patterns and chromatin dynamics in the nucleus.

This paper develops a biophysical model to explain how MreB filaments localize to curved surfaces in bacteria, showing that their curvature preference is governed by mean and Gaussian curvatures.

This study introduces a high-throughput method for epitope mapping using charged scanning mutagenesis and flow cytometry, identifying epitopes in SARS-CoV-2 RBD targeted by polyclonal sera.

This paper introduces a method to selectively trap glycated proteins in nanopores using reversible covalent bonds, improving the accuracy of protein size and shape analysis.

This study identifies a sequence-encoded mechanism in plant proteins that enables thermoresponsive phase separation through low-complexity domains.

The paper investigates optimizing labeling efficiency in MINFLUX 3D DNA-PAINT microscopy by improving marker detection probability through repeat DNA-PAINT and adjusting acquisition parameters.

This paper uses computational methods to study the structural disorder of Dsup and its interaction with the human nucleosome, revealing dynamic electrostatic shielding effects.

This study uses single-particle microscopy to analyze structural, size, and payload heterogeneity in mRNA-loaded lipid nanoparticles and correlates these properties with formulation parameters.

This paper introduces BPHON, a method that uses image analysis to score the fitness of protein structures against NMR spectra without requiring full resonance assignments.

RACLET is a reliable and valid test for critical power parameters in cycling, offering comparable accuracy without inducing exhaustion.

This study creates tunable Fe(II)-based glycoassemblies that mimic high-mannose glycans and inhibit their interactions with lectins.