Discover, rate, and discuss biology preprints.

This paper introduces DS3dRNA, a framework for de novo RNA design that uses higher-order interactions, achieving better performance than existing methods in structure prediction and function recovery.

The paper quantifies magnetofluorescence of MagLOV in mammalian cells and neurons, showing magnetic field effects across cell types.

The paper investigates how tubulin C-terminal tails respond to pH changes and shows their role in regulating microtubule interactions through protonation of glutamate residues.

The paper shows LC3B forms nanoclusters on autophagosomes via specific lipid interactions and a unique binding pocket, impacting autophagosome motility.

This study shows that the polyA/polyQ tract in Ascl1 regulates DNA engagement and aggregation through conformational changes, affecting solubility and cellular abundance.

This study designs de novo proteins that selectively inhibit alpha-synuclein aggregation by targeting specific intermediates, with one binder preferentially inhibiting oligomer formation and secondary nucleation.

The paper develops a simulation framework to infer nucleosome-resolution chromatin structures from RCMC data, revealing euchromatin as condensed domains with accessible promoter/enhancer regions.

This paper introduces a domain decomposition method to quantify mixing in disordered protein simulations, showing physicochemical similarity promotes mixing and identifying factors influencing condensate formation.

This paper uses third-harmonic generation microscopy to visualize and measure mucociliary transport in human airway epithelium models without staining or processing.

This study improves molecular dynamics models to better predict nanopore blockade currents from single-stranded DNA by refining force field parameters.

This paper introduces light Martini water, a modified water model that accelerates sampling in coarse-grained MD simulations without compromising accuracy.

In a minimal tau fibril model, residue 300/301 binds incoming peptide first and carries the most release-prone hydration water. Spin-labelling site 300 impairs locking and suppresses seeded growth.

This study uses enhanced sampling simulations to explore the conformational space of Gaussia luciferase, revealing structural dynamics and substrate-binding features not captured by existing methods.

This study models oscillatory and steady streaming flow of cerebrospinal fluid in the cranial subarachnoid space using a lubrication-based framework, showing that oscillatory forcing enhances solute transport.

This study shows that geometric confinement and substrate stiffness influence cardiomyocyte force generation differently, with confinement enhancing contractile stress and relaxation on physiological substrates.

The paper uses a liquid state machine to analyze antibody coalescence dynamics, identifying a biophysical liability linked to gel-like stiffening during droplet merging.

This study investigates the mechanical properties of Chara cell walls by removing calcium crosslinks or pectin, finding that pectin significantly affects strength, stiffness, and permeability.

This study develops a biophysical model to explain how cell traction forces change during osmotic shocks, showing that forces decrease despite increased cell size and that stiffer cells recover faster.

This study compares the structural and mechanical properties of actin bundles formed by CaMKII with those formed by canonical cross-linkers, revealing unique flexibility and curvature in CaMKII bundles.

This study shows how cornsnakes use redundant contacts and force redistribution to climb vertical surfaces, revealing biomechanical principles for agile robotics.