Author

Sharvari Mankame

Translational Genomics Research InstituteORCID 0000-0002-2058-0140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

Floris P BartheliD· 3 shared Arthur S. ThomasiD· 2 shared Christine E. BrowniD· 2 shared Matthew T. RichiD· 2 shared Melissa C. KnouseiD· 2 shared Phillip J. HuffmaniD· 2 shared Robert Christopher PierceiD· 2 shared Samantha J. WorobeyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

Floris P BarthelORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Patient-Derived Glioma Models Preserve Tumor Heterogeneity and Identify Stearoyl-CoA Desaturase1 (SCD1) as a Candidate Biomarker for Precision Immunotherapy

Margarita Gutova, Eric Ma, Heini M. Natri, Sean M. Sepulveda, Sharvari Mankame, Spencer Uyematsu, Jonathan C. Hibbard, Maryam Aftabizadeh, Xiujian Ma, Renate Starr, Brenda Aguilar, Julie Ostberg, Lisa A. Feldman, Massimo D’Apuzzo, Nicholas E. Banovich, , Christine E. Brown

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

DeepSomatic: Accurate somatic small variant discovery for multiple sequencing technologies

Jimin Park, Daniel E. Cook, Pi-Chuan Chang, Alexey Kolesnikov, Lucas Brambrink, Juan Carlos Mier, Joshua M.V. Gardner, Brandy McNulty, Samuel Sacco, Ayşe Gökçe Keşküş, Asher Bryant, Tanveer Ahmad, Jyoti Shetty, Yongmei Zhao, Bao Quoc Tran, , Kishwar Shafin

DeepSomatic is a deep learning method for detecting somatic variants from short-read and long-read sequencing data, outperforming existing callers, especially for indels.

Nature Biotechnology · Oct 16, 2025Peer-reviewedBioinformatics

Cell-Free DNA Reveals the Longitudinal Effects of Temozolomide Treatment and Host Co-Culture in Glioblastoma Models

Sharvari Mankame, Hersh Nanda, Maria Kyriakidou, Mimi Mbegbu, Nanyun Tang, Michael E. Berens, Floris P Barthel

This study shows that cell-free DNA (cfDNA) can track glioblastoma tumor burden and treatment response over time using in vitro models.

bioRxiv · Jul 12, 2025 · PreprintCancer Biology

Low frequency optogenetic deep brain stimulation of nucleus accumbens dopamine D1 or D2 receptor-containing neurons attenuates cocaine seeking selectively in male rats in part by reversing synaptic plasticity deficits

Sarah E. Swinford-Jackson, Matthew T. Rich, Phillip J. Huffman, Melissa C. Knouse, Arthur S. Thomas, Sharvari Mankame, Samantha J. Worobey, Robert Christopher Pierce

bioRxiv · Jan 23, 2023 · PreprintNeuroscience

High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats

Sarah E. Swinford-Jackson, Phillip J. Huffman, Melissa C. Knouse, Arthur S. Thomas, Matthew T. Rich, Sharvari Mankame, Samantha J. Worobey, Mateo Sarmiento, Ayanna Coleman, Robert Christopher Pierce

The paper tests if optogenetic stimulation of specific dopamine receptor neurons in the nucleus accumbens reduces cocaine seeking in male rats, finding it reduces seeking when targeting D2DR neurons.

Neuropsychopharmacology · Nov 29, 2022Peer-reviewedNeuroscience