Discover, rate, and discuss biology preprints.

The paper estimates heritability of gene expression traits in yeast hybrids and finds non-additive components account for 36% of phenotypic variance.

The paper develops chloroplast genome-based genetic resources for 12 subalpine tree and shrub species using genome skimming, identifying SNPs and SSRs for phylogeographic and conservation studies.

The paper develops a PCR method using mtDNA universal primers to detect and differentiate indigenous domestic animal species in Pakistan, providing a tool for meat traceability and combating adulteration.

GetPrimers is a computational tool for designing PCR-based genetic targeting primers, validated across multiple organisms and experimental setups.

This study shows that LSD1/KDM1A is essential for neural stem cell differentiation in mice, as its deletion causes perinatal lethality and brain defects, but motor neurons can still be generated.

This study infers sociocultural stratification in admixed American populations using genomic data and a mating model with ancestry-related assortative mating and sex bias parameters.

The paper identifies 119 high-confidence STR-trait associations across 93 STRs for blood and serum traits using imputed genotypes from UK Biobank data.

HapNe infers recent effective population size variation in modern and ancient DNA samples using IBD or LD, showing improved accuracy and efficiency.

This study identifies non-coding rare variant associations with blood traits in 166,740 UK Biobank genomes but finds most associations are driven by linkage disequilibrium with common variants.

This paper introduces a QTL mapping method using expected local genetic relatedness matrices derived from ancestral recombination graphs, improving detection of QTLs in populations with limited imputation resources.

This study analyzes genetic admixture and adaptation in South West coast India populations, revealing distinct lineage and early migration patterns from North West India.

The paper discovers a new shell color polymorphism in Lymnaea stagnalis and shows it follows simple Mendelian inheritance.

This study identifies a naturally occurring MBD4 variant in rhesus macaques that causes maternal germline hypermutation, leading to increased de novo mutations in offspring.

The paper identifies rare somatic mutations in sporadic ALS and FTD cases, suggesting they contribute to disease and widespread neurodegeneration.

The paper introduces a basepair-resolution mutation rate model, Roulette, which identifies a 10-fold increase in mutation rate for Polymerase III-transcribed genes and detects elevated rates in testis-specific transcription factor binding sites.

This study develops a CRISPR/Cas9 method to generate heritable mutations in Frankliniella occidentalis, demonstrating gene knockouts and phenotypic changes.

This paper introduces a multistage GSI method that integrates regional baselines to improve broad-scale stock identification without requiring overlapping markers or populations.

LoGoFunc predicts pathogenic gain- and loss-of-function variants using ensemble learning with diverse biological features, outperforming existing tools.

The paper shows that ATR and DDK control TopBP1-mediated locking of dormant origins at the pre-IC stage, with compensation involving both passive and active processes.

The paper describes the Gene-SOEP dataset, a longitudinal genetic study of 2,598 individuals in Germany, providing polygenic indices for research on genetic-environment interactions.