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The paper investigates how social environments interact with genetic factors related to educational attainment, finding that higher social mobility reduces genetic influence on educational outcomes.

The paper identifies a regulatory SNP rs60464856 that increases RUVBL1 expression and contributes to prostate cancer progression through cohesin-CTCF binding and cell-cycle activation.

The paper investigates how copy number variants (CNVs) in yeast affect mutational tolerance and fitness, finding both increased tolerance in translation-related genes and decreased tolerance in mitochondrial function genes.

The paper examines genetic differentiation in the sweat bee Halictus rubicundus at extreme latitudes, finding genetic isolation in northern Scotland compared to southern England, but genetic overlap across the Irish Sea.

This study identifies discrete intermediates in mouse meiosis crossover formation and shows distinct genetic roles for MLH3 in intermediate differentiation.

The paper analyzes genome-wide data from 52 ancient individuals in Cambridgeshire to show low genetic ancestry differentiation and limited genetic relatedness during the Roman occupation, with modern genetic patterns emerging after the Roman period.

This study identifies genomic transitions in mating-type locus organization in Malassezia and shows engineered strains exhibit hyphal development and upregulated mating-related genes.

The paper introduces a new assay, Recovery of Protein Synthesis (RPS), to measure TC-NER by tracking protein synthesis recovery after DNA damage, showing its utility in living cells and tissues.

This study identifies MANF as a regulator of autophagy and lysosome function, improving proteostasis and extending lifespan in C. elegans.

The paper identifies Abhd2 as an enzyme involved in metabolizing phosphatidylcholine and cardiolipin using genetic and lipidomic data from Diversity Outbred mice.

The paper shows that early treatment with RAS inhibitors in SHR reduces kidney renin expression and lowers blood pressure long-term through genetic and epigenetic changes.

This study uses hiPSC-derived cardiomyocytes to assess MYH7 variants' effects, showing pathogenic variants reduce protein abundance and cell survival.

This study examines how genomic selection affects allele frequencies and new mutations over fifty generations, finding that genomic selection leads to faster and larger changes in allele frequencies compared to pedigree selection.

The paper identifies genetic markers for anthracycline-induced cardiotoxicity risk by analyzing intermediate molecular phenotypes in mice and human cohorts.

This paper develops generative models that register and fuse multiple medical imaging modalities, revealing more genotype-phenotype associations through GWAS and PheWAS of learned embeddings.

The paper identifies a high-risk subgroup in myelodysplastic syndromes with isolated trisomy 8 using mutational profiles.

This paper shows that genomic data and local ancestry analysis can help remove hybrid DNA in captive breeding programs to prevent genetic swamping.

This study examines the distinct roles of RNase HII and HIII in removing RNA:DNA hybrids and their impact on mutagenesis and DNA replication.

This study shows that stac3 knockout in zebrafish mimics early life lipid overload and muscle weakness seen in Native American myopathy.

The paper introduces COAST, a rare variant association test for allelic series, which improves power over SKAT-O in detecting gene-trait associations in lipid and cell count traits using UK Biobank data.