Donnie S. Stapleton

Distinct genetic architectures of mRNA expression and splicing QTL in the Diversity Outbred mouse population

The paper maps eQTL, isoQTL, irQTL, and sQTL in DO mice, showing distinct genetic effects on mRNA expression and splicing, and identifies candidate genes and regulatory mechanisms.

Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin

The paper identifies Abhd2 as an enzyme involved in metabolizing phosphatidylcholine and cardiolipin using genetic and lipidomic data from Diversity Outbred mice.

A protocol for locating and counting transgenic sequences from laboratory animals using a map-then-capture (MapCap) sequencing workflow: procedure and application of results.

The paper presents a MapCap sequencing workflow to locate and count transgenic sequences in mice, identifying insertion sites and characterizing genetic variations in a diabetes model.

Systems genetics uncovers microbe-lipid-host connections in the murine gut

This study identifies genetic links between gut microbiota, lipids, and host transcripts in mice, revealing key roles for Akkermansia muciniphila and ornithine lipids in microbe-host interactions.

INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants

INFIMA identifies effector genes of GWAS variants by integrating multi-omics data from mice and applying it to diabetes-associated variants.

Genetic determinants of gut microbiota composition and bile acid profiles in mice

This study identifies genetic loci associated with gut microbiota composition and bile acid profiles in mice using QTL analysis and validation experiments.

Identification of Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets

The paper identifies Slco1a6 as a gene affecting gene expression in mouse pancreatic islets through eQTL analysis and functional studies.