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This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.

The paper uses a CRISPRi screen in hESC differentiation to identify enhancers with nonlinear regulatory activity, revealing a CTCF loop-constrained model for improved enhancer prediction.

This paper develops a Tamoxifen-inducible vWF Cre recombinase mouse strain to study microvascular endothelial cell-specific gene function in vivo.

This study identifies gex-3 as a suppressor of a PIEZO-1 gain-of-function mutation in C. elegans, revealing a role for the cytoskeleton in regulating PIEZO channel activity.

This study estimates heritability using Copy Number Variants (CNVs) and SNPs from UK Biobank data, finding a small CNV heritability for hypertension.

The paper identifies a symmetric structure in mitochondrial genetic codes of vertebrates, ascidians, and yeast, and shows how other codes evolve from it through small modifications.

This study identifies CTCF and cohesin as essential for chromatin-nuclear speckle association, showing their role in gene inducibility and relevance to disease.

isGWAS enables fast and scalable genetic association analysis using cohort-level summary data, achieving speeds up to 1500 times faster than existing methods.

The paper assesses correlations between feed efficiency (FE) and feeding behavior in rainbow trout using isogenic lines and indirect measurements.

The paper investigates the role of HbxA in Aspergillus nidulans, showing it regulates over 1,000 genes and affects secondary metabolite production.

This study develops and validates genetic manipulation techniques in betta fish, including CRISPR/Cas9 knockout, knockin, and Tol2 transgenesis, to enable functional studies of genes involved in viability and pigmentation.

The paper describes three patients with AGAP1 deletion variants and uses a Drosophila model to identify endolysosomal trafficking defects and stress response abnormalities linked to neurodevelopmental disorders.

The paper identifies epistasis between mutator alleles in mice, showing that combined mutator alleles at two loci increase C>A mutations compared to single mutator alleles.

This paper extends Finlay-Wilkinson regression by replacing the environmental index with synthetic covariates derived from observable environmental factors, enabling predictions for new environments.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.

This paper evaluates the cost-effectiveness of precision-guided sterile insect technique (pgSIT) for malaria control in The Gambia, finding it to be a cost-effective and economically beneficial approach.

This study examines epigenetic age acceleration and adaptation mechanisms in the Yakutian population using DNA methylation data, finding higher age acceleration and region-specific methylation patterns related to climate adaptation and aging.

The paper identifies complex on-target vector insertions in CRISPR-edited mouse cells using long-read sequencing, revealing that these insertions can escape standard PCR-based quality control.

The paper introduces a method to engineer tandem duplications in Drosophila using CRISPR and recombinases, showing increased ADH enzyme activity with varying duplication sizes.