Author

William A.C. Gendron

Mayo ClinicORCID 0000-0002-2280-3133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:gene regulatory network inference· 2 Organism:zebrafish· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrea L. SmidleriD· 2 shared Brandon W. SimoneiD· 2 shared John Macky MarshalliD· 2 shared Karl J. ClarkiD· 2 shared Omar S. AkbariiD· 2 shared Robyn R RabaniD· 2 shared Stephen Carl EkkeriD· 2 shared Agastya MondaliD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

Andrea L. SmidlerORCID

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Author profile →

4 papers

Recent·Most cited

Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load in Aedes aegypti

William A.C. Gendron, Andrea L. Smidler, Ming Li, Tyler Wise, Hector M Sanchez C., Jared B. Bennett, Robyn R Raban, John Macky Marshall, Omar S. Akbari

This study develops split suppression gene drives in Aedes aegypti, showing that inheritance efficiency and reproductive fitness costs must be balanced for effective population suppression.

bioRxiv · Sep 18, 2026 · PreprintBioengineering

Cost-effectiveness of Precision Guided SIT for Control of Anopheles gambiae in the Upper River Region, The Gambia.

William A.C. Gendron, Robyn R Raban, Agastya Mondal, Héctor M. Sánchez C., Andrea L. Smidler, David Zilberman, Patrick G. Ilboudo, Umberto D’Alessandro, John Macky Marshall, Omar S. Akbari

This paper evaluates the cost-effectiveness of precision-guided sterile insect technique (pgSIT) for malaria control in The Gambia, finding it to be a cost-effective and economically beneficial approach.

bioRxiv · Jul 20, 2023 · PreprintGenetics

Chimeric RNA:DNA Donorguide Improves HDR in vitro and in vivo

Brandon W. Simone, Han B. Lee, Camden L. Daby, Santiago Restrepo-Castillo, Gabriel Martínez‐Gálvez, Hirotaka Ata, William A.C. Gendron, Karl J. Clark, Stephen Carl Ekker

This paper introduces a Donorguide technology that improves HDR efficiency and precision by fusing an ssDNA template to tracrRNA, showing enhanced results in vitro and in vivo.

bioRxiv · May 28, 2021 · PreprintGenetics

Expanding The CRISPR Toolbox With Mad7 In Zebrafish And Human Cells

Wesley A. Wierson, Brandon W. Simone, Zachary WareJoncas, Carla M. Mann, Jordan M. Welker, Bibekananda Kar, Michael J. Emch, Iddo Friedberg, William A.C. Gendron, Michael A. Barry, Karl J. Clark, Drena L Dobbs, Maura A. McGrail, Stephen Carl Ekker, Jeffrey J. Essner

This paper characterizes ErCas12a, a new CRISPR/Cas system, showing it enables efficient DNA repair and gene integration in zebrafish and human cells.

The CRISPR Journal · Dec 1, 2019Peer-reviewedGenetics