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The paper uses single-cell RNAseq data to analyze genetic factors influencing cell-type composition in mouse tissues, identifying heritability and QTLs associated with cell-type abundance.

This study shows that TMEM106B affects myelination through a TFEB-dependent pathway in zebrafish, and TFEB inhibition rescues myelin defects caused by TMEM106B mutations.

The paper describes the International Mouse Phenotyping Consortium's data portal, its expansion to over 100 million data points, and improvements to its web interface and data access tools.

The paper identifies trans-regulatory variants associated with chromatin accessibility in maize hybrids, revealing their role in heterosis and gene expression.

The paper describes a non-organic DNA extraction protocol for orchids using CTAB-based gel preservation, sterile sand, and stabilization buffers, enabling high-quality DNA extraction from fresh and stored samples for genomic applications.

The paper correlates single-cell transcriptome data with gene drive performance by analyzing Cas9 promoter expression in different systems.

The paper identifies ATF4 as a target of Hbs1-Pelo translation regulation, showing its role in visual system development and function in Drosophila and human cells.

The paper identifies four types of fragile nucleosomes that facilitate RNA Polymerase II transcription in human cells by analyzing histone modifications and Pol II activity.

The paper quantifies genetic influences across educational milestones in two Norwegian cohorts, finding stage-specific heritability and declining genetic overlap with later degrees.

mrpast infers complex demographic histories from whole-genome genealogies, accurately recovering parameters like migration rates and population sizes in various models.

This study uses long-read sequencing to reveal extensive somatic mosaicism in FMR1 repeats and methylation in FXTAS brain tissue, identifying expansions and contractions beyond traditional methods' resolution.

The paper genomically rewrote a mouse Taf1 allele with a human XDP patient-derived TAF1 allele, revealing that intronic SVA retrotransposons reduce TAF1 levels and cause neurodegeneration.

The paper shows that maternal SETDB1 is essential for silencing 2-cell totipotency genes in mouse embryos, allowing development beyond the 8-cell stage.

This paper introduces FLEX, a method for estimating gene-level heritability from whole-exome sequencing data, showing rare coding variants contribute significantly to complex trait heritability.

This study identifies the minimal effective NTBC dose to prevent liver damage in HT1 using an in vitro model and validates it in 99 patients, while highlighting residual gene dysregulation linked to cancer risk.

The paper develops TLSCP, a transfer learning method for survival-based clustering of predictors, applied to TP53 mutation annotation, showing improved clustering and clinical interpretability.

The paper introduces Hi-Plex CUT&Tag, a method to detect co-localization of over 600 CRF pairs, enabling comprehensive analysis of chromatin regulatory interactions in a single experiment.

The paper compares genetic diversity between two hornbill species, finding the island-endemic Narcondam Hornbill has significantly lower genetic diversity than the Wreathed Hornbill.

This study shows that inhibiting miR132-3p with ASOs increases MECP2 mRNA in SH-SY5Y cells, suggesting a potential therapeutic approach for Rett syndrome.

This study identifies genetic loci associated with agronomic traits in grapevines using multiple QTL and GWAS approaches across 1,081 genotypes from a breeding program.