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Interaction of combined stressors and genetic background on recombination rate plasticity in Drosophila melanogaster

The paper examines how low temperature and hypoxia, alone and together, affect recombination rates in Drosophila melanogaster across different genetic backgrounds.

High-throughput Eukaryotic Screening of Putative Anti-CRISPR Proteins against SpyCas9 and SauCas9

The paper screens hundreds of anti-CRISPR homologs to inhibit SpyCas9 and SauCas9, revealing evolutionary patterns and discovering three novel Acr families.

Genome-scale base editing reveals the functional effects of variants in yeast

This study uses genome-scale CRISPR base editing in yeast to assess the functional effects of 308,461 variants, identifying 18,009 with significant growth impacts.

A hyperactivating mutation in formin-like 2 causes brain and vertebrae defects

This study identifies a hyperactivating mutation in Fmnl2 causing brain and vertebrae defects in mice through a forward genetics screen.

Local population genetic structure of Andrena flavipes (Hymenoptera, Andrenidae), a nest-philopatric communal mining bee, reveals isolation-by-distance and high inbreeding

The paper assesses genetic structure and inbreeding in Andrena flavipes bees using SNPs, finding isolation-by-distance and high inbreeding despite high genetic variation.

Combinatorial mosaics dissect the residue level basis of ACE2 binding divergence between SARS-CoV-2 and RaTG13

The paper constructs combinatorial RBD mosaics of SARS-CoV-2 and RaTG13 to identify residue-level differences affecting ACE2 binding affinity.

abcneuralnet: Simulation-based Inference with Bayesian Neural Networks and Explainable AI for Population Genomics Inference

abcneuralnet provides a Bayesian Neural Network framework with explainable AI for population genomics inference, offering calibrated prediction intervals and uncertainty decomposition.

The WD40 domain of autophagy protein ATG-16.2 is required for lysosomal regulation and longevity in germline-less C. elegans

Capturing Spatial Heterogeneity Using UAV-Derived Multispectral Phenotypes and Random Regression Models Improves Genetic Evaluation in Alfalfa Breeding Trials

The interferon-gamma response pathway is a targetable driver of FSHD muscular dystrophy progression

This study identifies the IFN-gamma pathway as a therapeutic target for FSHD by showing its role in driving inflammation and disease progression.

scRBP infers cell-specific RNA-binding protein regulons from single-cell transcriptomes at gene and isoform resolution

scRBP infers cell-specific RNA-binding protein regulons from single-cell transcriptomes, resolving targets at gene and isoform levels and linking genetic risk to disease.

Unveiling the intraspecific genomic diversity of South American lowland maize landraces

This study examines genomic diversity in South American lowland maize landraces from Uruguay and Brazil, finding geographic patterns in genome size, heterochromatic knobs, and repetitive sequences.

The usefulness of triploid sib records for selection of diploid candidates in rainbow trout breeding programs for growth, processing traits and hypoxia tolerance

This study evaluates using triploid sib records to improve diploid selection in rainbow trout breeding for growth, processing traits, and hypoxia tolerance, finding high genetic correlations and benefits for certain traits.

STING deficiency extends median lifespan and mitigates age-related liver pathology in mice

This study shows that STING deficiency in mice increases median lifespan and reduces age-related liver damage.

Understanding genetic and environmental complexity in phenotypic resemblance across relatedness in population-scale data

The paper evaluates non-linearities in phenotypic similarity versus genetic relatedness by analyzing three processes: imperfect tagging, assortative mating, and shared environments, using UK Biobank and All of Us data.

Sample overlap in genome-wide association meta-analysis: practical comparisons across significance thresholds

The paper evaluates the impact of sample overlap in GWAS meta-analysis across different significance thresholds and shows minimal impact when overlap is small.

Comparison of the performance of sporophytes derived from narrow and wide genetic crosses between strains of the cultivated kelp Saccharina latissima

This study compares local and wide genetic crosses in kelp to assess breeding effectiveness without introducing foreign genetic material.

Hybrid Drosophila genomes rapidly purge minority ancestry but repeatedly retain selected regions

The paper tracks genome-wide evolutionary dynamics in hybrid Drosophila populations, showing rapid purging of minority ancestry and repeated retention of selected regions through adaptive introgression.

Phenomic selection enables nursery screening for field performance in maize and pea

This paper demonstrates that UAV-based phenomic selection can predict field performance of nursery-grown maize and pea genotypes without genotyping.

Leveraging synthetic environmental covariates to explore crop genotype by environment interactions

The paper introduces a method to analyze genotype by environment interactions by examining environmental effects across growth stages, finding that early grain fill stages have the greatest impact on yield variance.