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SUMMIT traces mitochondrial mutations in human tissues to identify spatially localized clones and their transcriptomic profiles.

The paper identifies context-dependent regulatory variants in Alzheimer's disease by analyzing their effects across different cellular contexts using MPRAs and machine learning.

The paper shows that TRF1 loss in MEFs triggers inflammation via ATR/cGAS/STING and ATM/STING pathways by inducing DNA damage and cytosolic DNA.

The paper identifies alpha satellite RNA's role in marking the perinucleolar compartment and repressing rRNA expression in naive hESCs.

The paper characterizes gene expression and cell types in the silk glands of Plodia interpunctella, revealing transcriptomic differences between posterior and middle silk glands.

This study examines how king penguins mitigate the fitness costs of phenological mismatch through molecular stress response mechanisms.

The paper uses genomics and resistance assays to identify resistant individuals in two tree species affected by myrtle rust, highlighting the potential for genetic breeding programs.

Topsicle estimates telomere length from whole genome long-read sequencing data using k-mer and change point detection, showing robustness and accuracy in plant and human cancer cells.

The paper assesses genetic diversity of soil-transmitted helminths across regions and evaluates its impact on molecular diagnostic targets using low-coverage genome sequencing and in vitro assays.

The paper tests regulatory potential of conserved enhancers in thylacine and wolf to assess functional convergence over 160 million years of evolution, finding limited evidence of convergent divergence.

The paper uses long-read sequencing to analyze telomere-to-telomere assemblies in Populus trichocarpa, revealing complex KCS gene variation and its association with helitron transposons.

This study analyzes 114 C. fetus genomes to explore genetic diversity, antimicrobial resistance, and zoonotic potential across hosts and geographies.

This paper develops a hybridization capture method to enrich mitochondrial genomes of soil-transmitted helminths from fecal samples, achieving high enrichment and sensitivity.

The paper measures SLC6A6 mRNA expression in lymphoblastoid cell lines from Alzheimer's disease patients and finds it is 2.8-fold lower than in age-matched controls, suggesting a potential role for taurine in AD pathogenesis.

The paper describes the gene model for the ortholog of Glycogen synthase in Drosophila ananassae as part of a dataset for studying IIS pathway evolution.

The paper expands the DNA motif lexicon of transcriptional regulatory code by identifying composite elements and using a deep learning model to predict their activity and impact of variants.

This study identifies genes associated with monogermity and betalain biosynthesis in sugar beet through genome-wide association analysis of 290 accessions.

This study identifies novel protective genetic variants associated with TMT-B performance using a family-based GWLS approach in the Long Life Family Study.

This study investigates how TB and COVID-19 co-infection affects the sputum microbiome, finding altered bacterial abundance and functional pathways that may impact treatment outcomes.

This study examines differences between Infinium MethylationEPIC v1 and v2, showing high array-level concordance but probe-level variation, and recommends accounting for version differences in analyses.