Discover, rate, and discuss biology papers.

This paper develops and validates genome-based MLST typing for Histoplasma capsulatum using 406 genome assemblies, achieving lineage separation with >8,000 markers.

This study finds that intelligence and Big Five personality traits share substantial genetic and biological overlap, with 90% of genetic variants influencing personality traits also affecting intelligence.

The paper constructs a single-nucleus multi-omic atlas of adult human tissues, identifying regulatory elements and variant effects across 21 tissues.

This paper evaluates Evo 2's in-context learning capabilities on genomic sequences, finding strong performance on short sequences but degradation with length, and no benefit from model scaling.

The paper measures recombination rates between inversion haplotypes at 17q21.31, finds gene flux occurs despite suppression, and shows its impact on fertility and genetic diversity.

This study characterizes structural variation across 16 clownfish species, identifying extensive SVs and clarifying inversion events on chromosomes 18 and 9.

This study evaluates deep learning models for gene expression prediction in disease contexts, finding they perform poorly in disease-relevant applications despite high overall correlation.

CBS-tools identifies, phases, and annotates sex chromosomes using k-mer analysis from whole-genome sequencing data across multiple species.

The paper assembles the genome of Themeda triandra, finds syntenic relationships with sorghum, and identifies genetic variation linked to environmental adaptation.

The paper identifies molecular alterations in the prefrontal cortex of individuals with alcohol use disorder and smoking, revealing distinct and combined pathway changes across cell types.

The paper analyzes the evolutionary dynamics of IS6110 in Mycobacterium tuberculosis complex strains using ancestral state reconstruction and identifies patterns of insertion and selection.

This paper investigates how genomic mechanisms govern cell fate commitment in cancer by analyzing time-series transcriptomes and proposing a framework based on self-organized criticality and information thermodynamics.

GeoAdvAE integrates unpaired single-cell morphology and transcriptomics to align cell types and reveal disease-associated microglia signatures.

PfPHAST is a streamlined amplicon sequencing panel for malaria genomic surveillance, offering better quality control and cost efficiency than MAD4HatTeR without sacrificing performance on shared targets.

This study identifies genomic features, particularly copy-number alterations, that predict metastatic progression in melanoma and defines a six-gene signature associated with relapse.

SCAR introduces controlled mutations, fragmentation, and damage to sequencing data for benchmarking analyses affected by these factors.

This paper introduces BOB-seq, a method for isoform-resolved multiplexed RNA sequencing that uses bioorthogonal barcoding to capture full-length transcripts and improve splicing effect detection.

The study examines how genetic variation in mouse induced pluripotent stem cells affects gene expression and cell cycle responses to triphenyl phosphate exposure.

This study compares transcriptional heterogeneity in the cardiac conduction system across species and developmental stages using single-cell and spatial transcriptomic data.

The paper presents Hi-C data and 3D models for Podospora anserina to study its chromosomal spatial organization and aid multi-omics integration.