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363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- GenomicsbioRxivPreprintDOI 10.64898/2026.08.11.744104
- GenomicsbioRxivPreprint
CARD:Epi - Contextualizing Antimicrobial Resistance Determinants Using Deep Learning Language Models
Arman Edalatmand, Tiffany Erin Ta, Claire Zhao…·Andrew G. McArthur
The paper uses BioBERT to extract and analyze antimicrobial resistance gene transmission patterns from 204,094 publications, visualizing ARG spread across environments, hosts, and agriculture.
DOI 10.64898/2026.08.14.744850 - GenomicsbioRxivPreprint
Elevated isoform richness in males largely reflects transcriptional noise rather than proteomic complexity
Linley M. Sherin, Bernadette D. Johnson, Alberto Corral‐López…·Judith E. Mank
The paper uses long-read RNA-Seq to show that male isoform richness in Poecilia reticulata reflects transcriptional noise rather than proteomic complexity.
DOI 10.64898/2026.08.10.744030 - GenomicsbioRxivPreprint
A Conserved Regenerative Architecture Underlies Skeletal Muscle Repair in Adult Zebrafish
Mirjana Novković, Andjela Milicevic, Emilija Milošević…·Snežana Kojić
This study identifies a conserved regenerative program in adult zebrafish skeletal muscle repair following different injury types, showing shared transcriptional responses and functional modules.
DOI 10.64898/2026.08.12.744335 - GenomicsProceedings of the National Academy of SciencesPeer-reviewed
The Immunophenotype and Proviral Landscape of HIV-infected CD4 T Cells During Antiretroviral Therapy
Cyrille L. Delley, Sakshi Shah, Kevin M. Joslin…·Iain C. Clark
This study uses DAb-seq to analyze HIV-infected CD4 T cells on ART, revealing subset-specific differences in provirus maintenance and surface protein expression.
- GenomicsbioRxivPreprint
Chromosome-level genome assembly of the European leaf-toed gecko, Euleptes europaea
Josephine R. Paris, Linelle Ann L. Abueg, Sarah E. Pelan…·Daniele Salvi
The paper presents a chromosome-level genome assembly for the European leaf-toed gecko, providing a high-quality reference for studying genome evolution and sex chromosome dynamics.
DOI 10.64898/2026.08.10.744031 - GenomicsGenome Biology and EvolutionPeer-reviewed
Chromosome-level Genome Assembly of the Potato Leafhopper Empoasca fabae (Hemiptera: Cicadellidae)
Joshua Molligan, Florent Sylvestre, Edel Pérez‐López
This paper presents the first chromosome-level genome assembly of the potato leafhopper, revealing synteny with related species and providing a resource for genomic studies.
DOI 10.1093/gbe/evag207 - GenomicsbioRxivPreprint
A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors
Ansgar F. Stenzel, Antonis Athanasiadis, Georgios Dangas…·Eleftherios Michailidis
The paper develops CRISPR-Cas9 delivery methods for primary human hepatocytes to enable efficient gene editing and screening of HBV host factors.
DOI 10.64898/2026.08.10.743996 - GenomicsbioRxivPreprint
The relationship of genetic diversity and inbreeding to extinction risk across over 500 vertebrate diploid genomes
Amanda M. Gardiner, Richard Michael Durbin
The paper analyzes genetic diversity and inbreeding in 512 vertebrate genomes to assess their relationship with extinction risk, finding ecological factors are stronger predictors than genetic measures.
DOI 10.64898/2026.08.14.744813 - GenomicsbioRxivPreprint
Maternal diet and genetics shape the human milk metabolome
Kelsey E. Johnson, Yiran Duan, Andrew Youssef…·Ellen W. Demerath
This study identifies how maternal diet and genetics influence the human milk metabolome, showing diet explains the most variation and uncovering genetic associations with specific metabolites.
DOI 10.64898/2026.08.11.744248 - GenomicsiSciencePeer-reviewed
From deserts to forests: sequencing of the giant forest hog completes the genomic history of the African Suids
Marta Maria Ciucani, Sabhrina Gita Aninta, Nuno Filipe Gomes Martins…·Rasmus Heller
This paper presents the first whole-genome data for the giant forest hog, revealing its evolutionary relationship with warthogs and significant genetic differentiation between populations.
DOI 10.1016/j.isci.2026.117121 - GenomicsbioRxivPreprint
A meta-analysis of ancient and present-day Central Eurasian genome data to revise archaic hominin ancestry
Aigerim Rymbekova, Martin Kuhlwilm
This study analyzes ancient and present-day Central Eurasian genomes to assess archaic hominin introgression, finding stable levels of Neanderthal and Denisovan ancestry over time.
DOI 10.64898/2026.08.10.743976 - GenomicsbioRxivPreprint
Host gene-expression signatures accurately distinguish bacterial, viral, and inflammatory diseases in febrile children across multiple cohorts
Sandra Viz-Lasheras, Irene Rivero-Calle, Federico Martinón‐Torres…·Antonio Salas
The paper identifies host gene-expression signatures that distinguish bacterial, viral, and inflammatory diseases in febrile children across multiple cohorts, achieving high diagnostic accuracy.
DOI 10.64898/2026.08.11.744042 - GenomicsbioRxivPreprint✦ In-depth digest
Local ancestry inference identifies robust evidence of selection in Neolithic Europe
Local ancestry methods on 176 imputed Neolithic genomes disagree on tract lengths; replicated meta-analysis supports selection at SLC24A5 and FADS1/2, while HLA signals look artefactual.
2 citations - GenomicsbioRxivPreprint
African Green Monkey Cerebrospinal Fluid miRNome Captures Conserved miRNAs Relevant to Human Neurodegenerative Disease
Sara Dzigurski, Rashid Al-Abri, Xiaoting Li…·Bianca R. P. Brown
The paper characterizes the miRNome of African green monkey cerebrospinal fluid, identifying conserved miRNAs relevant to human neurodegenerative diseases and highlighting species-specific variations.
DOI 10.64898/2026.08.07.743104 - GenomicsJournal of HeredityPeer-reviewed
A chromosome-level genome assembly of a "living fossil", the tadpole shrimp Lepidurus arcticus (Pallas, 1793)
Marius A. Strand, Ole K. Tørresen, Jens Ådne Rekkedal Haga…·Kjetill S. Jakobsen
This paper presents the first chromosome-level genome assembly of Lepidurus arcticus, revealing genomic features and comparing it to a related species.
DOI 10.1093/jhered/esag067 - GenomicsbioRxivPreprint
Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes
Cynthia Wu, Andrey V. Bzikadze, Tian Han Xu…·Melissa Gymrek
Trex-QTL identifies trans-eQTLs with global effects on molecular phenotypes, showing improved power and replicating known loci in rat brain data.
DOI 10.64898/2026.08.07.743622 - GenomicsEnvironmental ArchaeologyPeer-reviewed
Towards an archaeological workflow for sedaDNA sample collection: methods and best practices for minimizing surface contamination
Kadir Toykan Özdoğan, Fabrício Furni, Ivo Laros…·Gerard Arjen de Groot
This paper proposes and tests sedaDNA sampling workflows for archaeologists to minimize surface contamination and improve data reliability.
1 citation - GenomicsbioRxivPreprint
Learning Discrete Cell and Niche Codes from Spatial Transcriptomics Using Dual Residual Vector Quantization
Sebastian Birk, Arpit Merchant, Amirhossein Vahidi…·Mohammad Lotfollahi
SQUINT learns discrete cell and niche codes from spatial transcriptomics data using residual vector quantization, outperforming baselines in identification and cross-section integration.
DOI 10.64898/2026.08.07.743490 - GenomicsbioRxivPreprint
Hidden in the genomic bycatch: insights into genome reorganization and population structure of the parasitic nematode Contortylenchus reversus
Yahir Campusano, German Lagunas‐Robles, Lewis Stevens…·Ryan Bracewell
The paper presents a chromosome-scale genome assembly of Contortylenchus reversus and analyzes its population structure and host associations using genomic data from host beetles.
DOI 10.64898/2026.08.07.743562