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This study investigates how IL-4 and TGF-β regulate inflammation and immune cell infiltration in mouse-adapted SARS-CoV-2 infection, finding that neutralizing these cytokines alters disease pathology.

This study identifies Paillotin as a novel Drosophila immune peptide regulated by the Imd pathway, showing increased susceptibility to specific infections in mutants.

This paper describes a simplified method for producing soluble TCRs in CHO cells with deglycosylation, enabling structural studies of TCR-pMHC complexes with high efficiency.

This study shows that antigen mobility affects B cell immune synapse dynamics and antigen capture efficiency, with high-mobility antigens being extracted faster and with better affinity discrimination.

This study shows that systemic TREX1 inhibition enhances anti-tumor immunity by increasing T cell infiltration and activity in tumors while sparing other tissues.

This study shows HIV-1 enhances IL-8 production in HSCs in response to LTA through histone H4K5 acetylation, contributing to liver fibrosis in HIV-positive individuals.

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

This paper designs multivalent RBD nanoparticle vaccines that overcome immune imprinting and provide broad protection against SARS-CoV-2 variants and sarbecoviruses.

This paper describes a method to rapidly enrich neoantigen-specific CD8 T cells from peripheral blood, achieving frequencies comparable to tumor-infiltrating lymphocytes over 28 days.

This study links autonomic neuropathy in HIV patients with increased type-1 cytokines and pro-inflammatory immunotypes associated with sympathetic and parasympathetic nervous system deficits.

This study characterizes IgT in grass carp, showing its role in mucosal immunity and developing a tool to assess immune responses to immersion vaccination.

This study introduces BCR-MERFISH to profile plasma cell clonality in situ using image-based single-cell transcriptomics, revealing microbiota-dependent changes and spatial distribution patterns in mice.

The paper develops a mathematical model of glioblastoma growth and immune interactions, showing that targeting TAMs to enhance their antitumoral properties could significantly improve treatment outcomes.

This paper evaluates a nasal SARS-CoV-2 vaccine candidate based on S2 and N proteins, showing broad antibody responses and mucosal immunity in mice.

This study demonstrates that the Hemopurifier device removes 98.5% of platelet microparticles from healthy human plasma in a 4-hour session.

This study shows that Ant2 deficiency enhances T-cell function and anti-tumor immunity by altering mitochondrial metabolism and metabolic reprogramming.

The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.

This study compares humoral immunity elicited by prefusion-like and postfusion forms of HCMV gB in mice, finding similar neutralization titers but differences in antibody binding and phagocytosis.

This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.

This study identifies Serpine1 as critical for Th17 cell differentiation and psoriasis, showing its therapeutic potential through genetic and pharmaceutical inhibition.