Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- NeurosciencebioRxivPreprint
Neural energy metabolism encodes directed communication across the human cortex
Roman Belenya, Samira Maria Epp, Antonia Bose…·Valentin Riedl
The paper uses energy metabolism to infer directed communication patterns in the human cortex, showing sensory systems drive higher-order networks and default mode networks act as receivers.
- NeurosciencebioRxivPreprint
A novel method for obtaining epileptic brain tissue for omic analyses using electrodes from a clinical stereoelectroencephalography study
Ninja Ehrnrooth, Salla M. Kangas, Alina Malyutina…·Erika Ignatius
This paper describes a method to obtain brain tissue for omic analyses using SEEG electrodes, showing concordant transcriptomic and proteomic findings across different epileptic zones.
DOI 10.64898/2026.09.01.747265 - NeurosciencebioRxivPreprint
ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction
Isha Ralhan, Ju-Young Bae, Nathanael Y.J. Lee…·Maria S. Ioannou
This study shows ApoE4 impairs astrocyte lipid droplet formation by disrupting endolysosomal function and demonstrates that PCSK9 can restore lipid droplet formation by preventing ApoE4 internalization.
DOI 10.64898/2026.09.01.748585 - NeurosciencebioRxivPreprint
Mice, marmosets and humans use ambiguous local motion to stabilize gaze
Federica Bianca Rosselli, Marc Büttner, Annalisa Bucci, Felix Franke
The paper shows that mice, marmosets, and humans use ambiguous local motion signals from the retina to directly control eye movements without resolving the ambiguity.
- NeurosciencebioRxivPreprint
A neuro-computational approximation of the qualities of mental images
Rico Stecher, DANIEL H. KAISER
This paper develops a neuro-computational approach to assess mental image qualities using EEG and AI-generated images, finding that blurred and low contrast images align better with human alpha activity.
DOI 10.64898/2026.08.25.747062 - NeurosciencebioRxivPreprint
Predictive learning with local plasticity in excitatory-inhibitory networks
Henrique Aguiar, Matthias H. Hennig
This paper shows that excitatory-inhibitory networks with local plasticity can perform predictive inference without explicit error representations, using a BCM-like rule to maintain weights on a consistency manifold.
DOI 10.64898/2026.08.31.748357 - NeurosciencebioRxivPreprint
Rapid Mechanistic Bridging of an Alzheimer's Disease Plasma Protein Staging Panel Across Brain Proteomics Cohorts
Charles C. Kim, Meghan Kerrisk Campbell, Maximilien Burq…·Peter Cimermančič
The paper evaluates a seven-protein plasma panel across brain proteomics cohorts to show its association with AD proteomic changes.
DOI 10.64898/2026.08.31.748393 - NeurosciencebioRxivPreprint
A single-nucleus regulatory atlas links transposable elements to adult hippocampal neurogenesis
Umut Çakır, Federica Mantovani, Souad Youjil Abadi…·Manvendra Singh
This study uses snATAC-seq and snRNA-seq to identify TE-derived regulatory elements involved in adult hippocampal neurogenesis in response to rhEPO stimulation.
DOI 10.64898/2026.08.31.748376 - NeuroscienceScience AdvancesPeer-reviewed
Learning induces activation-mechanism--dependent neural plasticity in an intracortical microstimulation task
Robin Kim, Roy Lycke, Pavlo Zolotavin…·Lan Luan
Learning alters neural responses to ICMS, revealing differences between direct activation and network activity linked to behavior.
DOI 10.1126/sciadv.aef0343 - NeurosciencebioRxivPreprint
Early Life Adversity Produces Enduring Molecular and Functional Disruption of Developing Vagal Circuits
Sadie Panvini, Sirajan Kamara, Matt Hong, Pat R. Levitt
This study shows that early life adversity disrupts vagal circuit development in mice, with sex-specific changes in mitochondrial function and autonomic stress responses.
- NeurosciencebioRxivPreprint
Shared Neural Responses and Individualised Emotional Experience: An fMRI Study of Music Listening and Anhedonia
Ayse Nilay Kamaci, Yanxing Chen, Marie‐Stephanie Cahart, Owen O’Daly
This study examines neural synchrony and emotional responses during music listening in individuals with varying levels of anhedonia using fMRI and continuous emotional ratings.
- NeurosciencebioRxivPreprint
Universality Meets Cultural Nuances: Affective Responses to Rhythmic and Harmonic Complexity Across Cultures
Mathias Klarlund, Hua Shan, Tomas Edward Matthews…·Peter Vuust
The paper investigates affective responses to rhythmic and harmonic complexity in Chinese and Danish listeners, finding universal patterns in rhythmic sensitivity and cultural differences in harmonic responses.
DOI 10.64898/2026.08.31.748217 - NeurosciencebioRxivPreprint
Diffusion tensor imaging of whole human brains during long-term formaldehyde fixation: Temporal evolution of diffusion parameters, post-mortem conditions, and dependence on tissue structure
Nina Lüthi, Francisco J. Fritz, Björn Fricke…·Siawoosh Mohammadi
This study examines how post-mortem tissue conditions and fixation progression affect diffusion tensor imaging parameters in whole human brains, finding that mean diffusivity is a robust marker while fractional anisotropy requires microstructure-aware interpretation.
- NeurosciencebioRxivPreprint
Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons
Ashlesha Gogate, Wei-Chen Chen, Mpathi Nzima…·Maria H. Chahrour
This study uses CRISPRi Perturb-seq to analyze 1,408 autism risk genes in human cortical neurons, identifying 215 genes that cause global transcriptomic dysregulation and uncovering shared transcriptional pathways.
- NeurosciencebioRxivPreprint
Sex and APOE Genotype Differentially Shape Microglial Transcriptomic Profiles Across the Hippocampus and Cortex
Sandra Ledesma‐Corvi, Samantha A. Blankers, Andrew J. McGovern…·Liisa A.M. Galea
This study shows that female sex and APOEe4 genotype differentially affect microglial transcriptomic profiles in the hippocampus and cortex of mice.
DOI 10.64898/2026.08.31.748388 - NeurosciencebioRxivPreprint
An Integrated Single-Nucleus Atlas Resolves Cell-Type-Specific Programs and Molecular Subtypes in Alzheimer's Disease
Negin Rahimzadeh, Samuel Morabito, Saniya Khullar…·Vivek Swarup
The paper constructs a single-nucleus transcriptomic atlas of Alzheimer's disease and identifies cell-type-specific molecular subtypes and therapeutic targets using a new framework.
- NeurosciencebioRxivPreprint
tACS increases alpha burst duration in a frequency- and montage-specific manner
Julio Rodriguez‐Larios, Anna Ragone, Satyam Chauhan…·Caroline Di Bernardi Luft
This study shows that tACS at 10 Hz in posterior regions increases alpha burst duration, but not cognitive performance or resting state cognition.
DOI 10.64898/2026.08.31.747228 - NeurosciencebioRxivPreprint
Retrieval uncertainty drives rapid consolidation of confabulated memories in retrosplenial cortex
Aditya Singh, Nirupam Das, Palash Ahuja…·J. Balaji
The paper shows that retrieval uncertainty in retrosplenial cortex drives rapid consolidation of confabulated memories, with implications for Alzheimer's and aging.
- NeurosciencebioRxivPreprint
CAMSAP3 loss of function models suggest causative role in generalized genetic epilepsy
Christopher M. LaCoursiere, Zachary Stayn, Hannah Hepner…·Annapurna Poduri
The paper shows that CAMSAP3 loss of function leads to microtubule acetylation dysregulation and epileptic features in zebrafish and cultured cells.
DOI 10.64898/2026.09.01.744686