Discover, rate, and discuss biology preprints.

The paper generates iPSC-derived hepatocytes from NAFLD patients to identify disease-specific gene expression profiles without metabolic challenge.

This study investigates cadherin-6's role in thrombosis using murine models, finding that blocking or deleting cadherin-6 delays occlusion, while human platelets express it but murine do not.

This study investigates whether skin surface temperature variation explains Buruli ulcer lesion distribution, finding a weak inverse correlation between cooler skin temperatures and higher lesion incidence.

The paper identifies biallelic somatic fumarase variants in FH-deficient uterine leiomyomas and estimates germline FH variant carrier frequency.

This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.

The paper investigates the expression of FURIN and ACE2 in oral epithelial cells and finds they may facilitate SARS-CoV-2 entry through two potential routes.

This study uses an agent-based model to analyze how truck contamination and information sharing affect foot-and-mouth disease spread in U.S. cattle production systems, showing increased disease spread with indirect contact and improved resilience with information sharing.

This paper develops a knowledge repository for Zika virus research to rapidly integrate pathophysiological knowledge during outbreaks, enabling faster response and hypothesis generation.

The paper develops and validates a real-time RT-PCR test called PospiSense for detecting seven pospiviroids in pepper and tomato seeds.

The paper reviews histopathologic findings of endometrial biopsies in urban Ethiopia, finding endometrial polyps as the most common result and highlighting issues with sample adequacy.

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

This study shows that severe equine asthma causes pulmonary artery remodeling with increased smooth muscle mass, which is partially reversible by antigen avoidance but not corticosteroids.

This study shows that nimodipine prevents spasticity after spinal cord injury in mice by targeting neuronal CaV 1.3 channels.

This paper tests a new automated chilled release system for sterile male tsetse flies, finding it maintains flight and mating competitiveness but reduces survival.

This study tests whether AF-16 modulates sepsis symptoms in fecal peritonitis but finds no significant differences between AF-16 and saline groups.

This study shows that Pepper mild mottle virus (PMMoV) genomic RNA has polyadenylated 3' tails, allowing oligo(dT)18 priming despite lacking poly(A) tails in its 3' UTR.

This study presents the first 3D images of COVID-19 lung autopsy tissues using high-resolution cleared tissue microscopy, offering new insights into disease processes contributing to mortality.

This study investigates python nidoviruses, finding they infect multiple tissues beyond the respiratory tract and spread systemically via monocytes, challenging previous understanding of their tropism and disease patterns.

This paper develops a smartphone-based microscope method to detect Cryptosporodium and Giardia (oo)cysts in vegetables and water, achieving comparable recovery rates to commercial microscopes.

This paper compares machine learning algorithms for estimating residual tumour cellularity in breast cancer treated with neoadjuvant therapy, finding Support Vector Machines to be the most accurate.