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This study identifies tissue-specific genetic responses to ophidiomycosis in snakes using transcriptome analysis, revealing chronic inflammation and temperature-dependent host responses.

This study examines DNA methylation in genes associated with schistosomiasis-associated bladder cancer in children and bladder cancer tissues, finding methylation in tumor suppressor genes linked to the disease.

This study examines SNCA transcription in neurons with different -syn cytopathologies in LBD, finding preserved transcripts in non-Lewy body types and reduced in Lewy bodies.

This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.

This study shows that Klf4-dependent transitions in adventitial progenitor cells affect plaque stability in atherosclerosis by altering fibroblast, SMC, and macrophage phenotypes.

This study shows niacinamide enhances LL37's ability to disrupt SARS-CoV-2 membranes, suggesting it could improve AMP-based therapies for COVID-19.

EZH2 inhibition causes repeat misexpression and B cell death by mimicking viral infection in splenic B cells.

The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.

This paper develops a deep learning pipeline for automated AML diagnosis and molecular characterization using flow cytometry data, achieving high accuracy in classification and variant prediction.

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

This study shows that periodontitis promotes neuroinflammation via bacterial extracellular vesicles that cross the blood-brain barrier and activate TLR4/TLR8 signaling in the brain and trigeminal ganglion.

This study shows that exogenous TGFβ1 and its mimic HpTGM reduce inflammation and infarct size after myocardial infarction, improving cardiac outcomes.

This study measures blood flow velocity in the internal jugular vein under varying intrapulmonary pressure and gravitational conditions in healthy volunteers.

This study shows that deleting Pax2 and Pax8 in proximal tubules reduces acute kidney injury severity and prevents chronic disease by inducing protective gene expression similar to preconditioning.

HistoMIL simplifies training Multiple Instance Learning models on histopathology slides, achieving up to 85% AUROC for cancer gene prediction.

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

This study shows that simultaneous deletion of Pten and p53 in endometrial epithelial cells leads to epithelial to mesenchymal transition and the formation of uterine carcinosarcomas in vivo.

This study shows that reducing HS sulfation in neurons slows prion disease progression by enhancing prion protein clearance and reducing plaque formation.