Discover, rate, and discuss biology preprints.

This paper develops a novel scIHC analysis pipeline to study spatial interactions between plasmablasts and plasmacytoid dendritic cells in lymph nodes from head and neck cancer patients.

The paper reports overexpression of MGAT5 products in primary osteoblastic osteogenic sarcoma and links it to neoangiogenesis and tumor expansion.

This paper shows that Toxoplasma gondii infection changes dendritic cell durotaxis by altering F-actin structure and FAK phosphorylation, promoting parasite brain dissemination.

The paper builds a visual-language foundation model for pathology AI using a large dataset of pathology images and natural language descriptions curated from medical Twitter.

This study investigates the role of joint instability in osteoarthritis progression using a rat model, finding that joint instability exacerbates cartilage degeneration and that TGF-β1 inhibition may reduce synovial inflammation.

This study shows that altered muscle niche in D2-mdx mice leads to poor myogenesis and increased degeneration, but reversing this improves regeneration in adult mice.

This study identifies detyrosinated microtubules as a driver of myofibrillar malformations in dystrophic skeletal muscle fibers, linking increased deTyr-MT levels to structural impairments.

This study evaluates the effects of sodium nitrite reduction, removal, and replacement in ham on microbiological safety, colon health, and colorectal cancer risk in a rat model.

This study shows that a western diet impairs T regulatory cell function in NAFLD, leading to chronic inflammation and fibrosis, and suggests restoring Treg function as a potential therapy.

This study shows that deleting smooth muscle O-GlcNAc transferase (smOGT) reduces atherosclerosis in hyperglycemic ApoE-/- mice fed a Western diet.

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

This paper develops a thermosensitive hydrogel DDS for sustained delivery of anti-TNF and anti-VEGF drugs, showing long-term ocular protection after corneal injury.

This study investigates the role of platelet activating factor (PAF) signaling in hyperoxic neonatal lung injury and BPD by comparing WT and PAF receptor knockout mice.

The paper reports the first cases of H5N1 avian influenza in wild mammals in the US, showing neurological symptoms and lesions linked to bird-to-mammal spillover.

This study uses immunohistochemistry with a new antibody to show GPER expression varies across normal and cancer tissues.

The paper proposes a domain adaptation method for histopathology images that addresses class imbalance and improves transfer learning from labeled source to unlabeled target domains.

The paper models lineage displacement and coexistence in Phytophthora infestans using pathogenesis data to predict genotype fitness and composition changes across hosts.

The paper models COVID-19 as a continuous-time stochastic process to analyze extinction chances and outbreak patterns without considering immune individuals.

This study identifies a conserved microtubule-binding region in XopL that is essential for plant cell death, showing how effector localization relates to function across Xanthomonas species.

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.