Author

T. W. Ridky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2

Frequent Co-Authors

C. A. Natale· 4 shared J. T. Seykora· 2 shared M. Doepner· 2 shared A. Blanco· 1 shared A. Dahal· 1 shared A. Trautz· 1 shared B. C. Capell· 1 shared B. S. Katzenellenbogen· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCancer Biology

C. A. Natale

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Analysis of human GPER expression in normal tissues and select cancers using immunohistochemistry

C. A. Natale, J. T. Seykora, T. W. Ridky

This study uses immunohistochemistry with a new antibody to show GPER expression varies across normal and cancer tissues.

bioRxiv · Mar 9, 2023 · PreprintPathology

Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation

S. Huang, P. Kuri, J. Zou, A. Blanco, M. Marshall, G. Rice, S. Prouty, T. Dentchev, M. Doepner, J. D. Boerckel, B. C. Capell, T. W. Ridky, P. Rompolas

This study shows that mechanical stress induces stress vesicles in epidermal stem cells, which are linked to cell fate and regulated by Piezo1 and calcium dynamics.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

M. Doepner, C. A. Natale, I. Y. Lee, S. Venkat, S. H. Kim, J. A. Katzenellenbogen, B. S. Katzenellenbogen, M. Feigin, T. W. Ridky

This study identifies CHRM1 as a druggable melanoma target influenced by genetic variation in DOPA production, showing DOPA inhibits CHRM1 to suppress melanoma proliferation.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology

ZIP9 is a Druggable Determinant of Sex Differences in Melanoma

C. Aguirre-Portoles, R. Payne, A. Trautz, J. K. Foskett, C. A. Natale, J. T. Seykora, T. W. Ridky

The paper identifies ZIP9 as a target of testosterone in melanoma and shows that androgen receptor inhibitors can block ZIP9 to suppress melanoma growth in males.

bioRxiv · Mar 12, 2020Cancer Biology

Non-classical estrogen signaling inhibits melanoma and improves response to PD-1 blockade

C. A. Natale, J. Li, J. Zhang, A. Dahal, B. Z. Stanger, T. W. Ridky

This study shows that GPER activation inhibits melanoma growth and enhances response to PD-1 blockade by promoting differentiation and reducing immune suppressive proteins.

bioRxiv · Jun 6, 2017Cancer Biology