Author

R. Raeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. P. Monga· 3 shared A. Bell· 2 shared A. D. Singhi· 2 shared A. Singhi· 2 shared J. Tao· 2 shared K. Nejak-Bowen· 2 shared M. Poddar· 2 shared P. B. Pal· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPathology

S. P. Monga

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease

S. Chaudhary, R. P. Rai, P. B. Pal, D. Tedesco, A. D. Singhi, S. P. Monga, A. Grakoui, S. S. Iyer, R. Raeman

This study shows that a western diet impairs T regulatory cell function in NAFLD, leading to chronic inflammation and fibrosis, and suggests restoring Treg function as a potential therapy.

bioRxiv · Mar 23, 2023 · PreprintPathology

Selective targeting of α4β7/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

B. Gupta, R. P. Rai, P. B. Pal, S. Chaudhary, A. Chiaro, S. Seaman, A. D. Singhi, S. P. Monga, S. S. Iyer, R. Raeman

This study shows that targeting the α4β7/MAdCAM-1 axis reduces proinflammatory T cell recruitment to the liver, thereby suppressing liver fibrosis progression in a mouse model.

bioRxiv · Feb 20, 2023 · PreprintImmunology

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

S. Hu, J. Russell, S. Liu, R. Rai, K. Kosar, J. Tao, E. Hurley, M. Poddar, S. Singh, A. Bell, D. Shin, R. Raeman, A. Singhi, K. Nejak-Bowen, S. ko, S. P Monga

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

eLife · Oct 5, 2021Peer-reviewedPathology

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

S. Hu, L. M. Molina, J. Tao, S. Liu, M. Hassan, S. Singh, M. Poddar, A. Bell, D. Sia, M. Oertel, R. Raeman, K. Nejak-Bowen, A. Singhi, J. Luo, S. P. Monga, S. Ko

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

bioRxiv · Dec 3, 2020 · PreprintCancer Biology