S. Chaudhary

Citizenship status and career self-efficacy: An intersectional study of biomedical trainees in the United States

This study finds that non-citizen biomedical trainees in the US have lower career self-efficacy than citizen trainees, with non-citizen women showing the lowest levels.

TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair in back pain conditions

This study identifies TNFR1-mediated senescence and limited TNFR2 signaling as barriers to intervertebral disc cell repair in back pain, suggesting immunomodulation as a therapeutic strategy.

Lung Mycobacterium tuberculosis infection perturbs metabolic pathways in non-pulmonary tissues

This study shows that Mtb infection alters amino acid metabolism in non-pulmonary tissues of mice, with age-specific metabolic changes observed in different tissue types.

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease

This study shows that a western diet impairs T regulatory cell function in NAFLD, leading to chronic inflammation and fibrosis, and suggests restoring Treg function as a potential therapy.

Selective targeting of α4β7/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

This study shows that targeting the α4β7/MAdCAM-1 axis reduces proinflammatory T cell recruitment to the liver, thereby suppressing liver fibrosis progression in a mouse model.

Host immunosenescence compromises Mycobacterium tuberculosis clearance

This study shows that immunosenescence in older mice impairs Mycobacterium tuberculosis clearance, linked to mitochondrial dysfunction and altered immune cell responses.

Rab7 dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

This study shows Rab7 regulates CLCA1 in goblet cells, affecting mucus composition and gut microbiota, leading to increased susceptibility to colitis.

Dysregulated cysteine metabolism leads to worsened liver pathology in diabetes-tuberculosis comorbid mice.

This study identifies dysregulated cysteine and retinol metabolism in diabetic-tuberculosis comorbid mice as contributors to worsened liver pathology.

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

This study evaluates a new live-attenuated LSD vaccine, showing it is safe, immunogenic, and effective in protecting cattle against LSD with high seroconversion rates.

Career Self-Efficacy Disparities in Underrepresented Biomedical Scientist Trainees

This study examines disparities in career self-efficacy among underrepresented biomedical trainees, finding associations with race, ethnicity, gender, and career interests.

Detection and Role of Feline Apolipoprotein B mRNA-editing Enzyme Catalytic Polypeptide Subunit 3G-Like Protein in Feline Cells and Tissues

This study detects fA3G-like protein in feline cells and tissues and shows its expression is abrogated in lytic but not latent FIV infection.

Comprehensive studies of Head Maralla, Punjab, Pakistan vegetation for ethnopharmacological and ethnobotanical uses and their elaboration through quantitative indices

This study examines the ethnobotanical and ethnopharmacological uses of vegetation in Head Maralla, Punjab, Pakistan, identifying species and habitats for conservation.

1q21.3 amplification modulates therapy sensitivity in Triple-Negative Breast Cancer

The paper identifies 1q21.3 amplification as a genetic marker linked to therapy sensitivity in Triple-Negative Breast Cancer.

Fast, versatile, and quantitative annotation of complex images

The paper introduces a smartphone app for fast and accurate annotation of complex images, demonstrating its efficiency on biological data with speeds 130 times faster than existing methods.