Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PathologybioRxivPreprint
Hepatic fibrosis induced zinc-deficient dermatosis in American alligators (Alligator mississippiensis)
I. M. Piras, A. Bezuidenhout, J. Diaz-Delgado…·P. A. Kelly
This study investigates the pathogenesis of 'double scale' defects in American alligators, linking them to zinc deficiency and liver fibrosis caused by portal hypertension and chronic vitamin A toxicity.
DOI 10.1101/2022.08.30.505809 - PathologybioRxivPreprint
Automatic Sample Segmentation & Detection of Parkinson's Disease Using Synthetic Staining & Deep Learning
B. M. Pearce, P. L. Coetzee, D. Rowland…·S. Gentleman
This paper develops an automatic tool for Parkinson's Disease detection using synthetic staining and deep learning, achieving >90% accuracy on single 1000um brain regions.
- PathologybioRxiv
Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders
R. Ge, R. Sassi, L. Yatham, S. Frangou
The paper identifies three distinct brain maturational subtypes in youth with mood and anxiety disorders using neuroimaging data, showing differences in cortical-subcortical maturation and cognitive function.
- PathologybioRxivPreprint
Cardiomyocyte alpha-1A adrenergic receptors mitigate post-infarct remodeling and mortality by constraining necroptosis
J. Zhang, P. B. Sandroni, W. Huang…·B. C. Jensen
This study shows that cardiomyocyte alpha-1A adrenergic receptors reduce post-infarct mortality and remodeling by limiting necroptosis, with clinical evidence linking beta-blocker use to increased MI mortality.
DOI 10.1101/2022.08.29.505687 - PathologybioRxivPreprint
Graph neural networks ameliorate potential impacts of imprecise large-scale autonomous immunofluorescence labeling of immune cells on whole slide images
R. Reddy, R. Reddy, C. Sharma…·J. Levy
This study uses graph neural networks to improve TIL classification on whole slide images by leveraging contextual features from immunofluorescence labeling.
- PathologybioRxivPreprint
Unraveling the genetic architecture of the adaptive potential of Arabidopsis thaliana to face the bacterial pathogen Pseudomonas syringae in the context of global change
F. Roux, C. Bartoli, M. Riga, B. Mayjonade
The paper investigates the genetic basis of Arabidopsis thaliana's adaptive response to Pseudomonas syringae under climate change by identifying polygenic traits and QTL regions associated with disease resistance.
DOI 10.1101/2022.08.26.505380 - PathologybioRxiv
Inoculum and disease dynamics of citrus greasy spot caused by Zasmidium citri-griseum in sweet orange in Panama
V. Aguilera-Cogley, E. Sedano, A. Vicent
This study examines the dynamics of citrus greasy spot caused by Zasmidium citri-griseum in Panama, linking defoliation, inoculum production, and environmental factors to inform sustainable disease management.
DOI 10.1111/ppa.13703 - PathologybioRxivPreprint
Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice
E. Yamasaki, P. Thakore, S. Ali…·S. Earley
This study identifies impaired SR Ca2+ signaling and disrupted ion channel activity in Col4a1 mutant mice as contributors to age-related cerebral small vessel disease.
DOI 10.1101/2022.08.24.505186 - PathologybioRxiv
Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5
R. A. Cuevas, L. Hortells, C. Chu…·C. St. Hilaire
This study identifies TERT's non-canonical role in osteogenic reprogramming of aortic valve cells through STAT5, offering a potential therapeutic target for calcific aortic valve disease.
- PathologybioRxivPreprint
Immunohistochemical diagnosis of Trypanosoma vivax in experimentally infected sheep tissues
L. F. N. do Nascimento, T. G. de Cristo, F. Z. Salbego…·L. C. Miletti
This study demonstrates the detection of Trypanosoma vivax in formalin-fixed tissues of experimentally infected sheep using immunohistochemical techniques with polyclonal antibodies.
DOI 10.1101/2022.08.22.504753 - PathologybioRxiv
Resistance of Musa balbisiana accessions of the Philippines to banana bunchy top virus
N. A. M. Perez, F. M. Dela Cueva, A. F. A. Benjamin…·J. E. Thomas
This study identifies resistance to banana bunchy top virus in wild Musa balbisiana accessions, showing they remain symptomless and PCR-negative in both greenhouse and field conditions.
DOI 10.1094/pdis-10-22-2427-sc - PathologybioRxivPreprint
Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: a Bayesian latent class analysis
B. Calvo-Urbano, E. Leger, I. Gabain…·J. P. Webster
This study evaluates the sensitivity and specificity of the POC-CCA test for detecting livestock schistosomiasis in Senegal, finding variable performance by parasite species and location.
DOI 10.1101/2022.08.17.504243 - PathologybioRxivPreprint
Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome
M. Chen, C. Cavinato, J. Hansen…·M. A. Schwartz
This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.
DOI 10.1101/2022.08.16.504169 - PathologybioRxivPreprint
Resistance screening and in-silico characterization of cloned novel RGA from multi race resistant Lentil germplasm against Fusarium wilt (Fusarium oxysporum f. sp. lentis)
N. K, R. Singh, S. C. Dubey…·D. Kamil
The paper screens lentil germplasm for Fusarium wilt resistance and identifies novel RGA genes, which may be used to develop markers for functional resistance genes.
DOI 10.1101/2022.08.16.504179 - PathologybioRxiv
Beneficial Effects of Bempedoic Acid Treatment in Polycystic Kidney Disease Cells and Mice
K. R. Hallows, H. Li, B. Saitta…·N. M. Pastor-Soler
This study shows that bempedoic acid reduces cyst growth in ADPKD cells and mice, and combining it with tolvaptan enhances therapeutic effects.
DOI 10.3389/fmolb.2022.1001941 - PathologybioRxiv
Bovine polyomavirus-1 (Epsilonpolyomavirus bovis): An emerging fetal pathogen of cattle that causes renal lesions resembling polyomavirus-associated nephropathy of humans
F. Giannitti, C. da Silva Silveira, H. Bullock…·M. Castells
This paper describes pathological findings in a bovine fetus naturally infected with BoPyV-1, demonstrating its pathogenicity and potential to cause renal lesions similar to human polyomavirus-associated nephropathy.
DOI 10.3390/v14092042 - PathologybioRxivPreprint
"METAVIR score Ultrasound" - Pictorial Essay of Anatomy / Ultrasound / Elastography / Histology
L. J. de Oliveira Andrade, L. M. de Oliveira, G. C. Matos de Oliveira
The paper correlates ultrasonographic and elastography features with histological METAVIR scores in hepatitis C liver fibrosis using image composition.
- PathologybioRxiv
Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson ' Disease
Y. Chu, W. D. Hirst, H. J. Federoff…·J. H. Kordower
This study investigates whether tau pathology precedes dopaminergic neurodegeneration in Parkinsonism by comparing groups with and without synucleinopathy.
DOI 10.1093/brain/awad388 - PathologyPLOS Neglected Tropical DiseasesPeer-reviewed
Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus
L. Raasch, K. Yamamoto, C. M. Newman…·D. M. Dudley
This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.
DOI 10.1371/journal.pntd.0010623