Discover, rate, and discuss biology preprints.

This study conducted SARS-CoV-2 surveillance in urban wildlife in Ontario and Quebec, Canada, finding no evidence of viral RNA or neutralizing antibodies in tested samples.

This study uses deep learning to predict neoadjuvant chemotherapy benefit in breast cancer using stromal histology, introducing the TS-score which outperforms existing predictors.

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

This study identifies PnPf2 as a central transcriptional regulator of virulence in Parastagonospora nodorum by characterizing its genomic targets and associated transcription factors.

This study compares the inflammatory, neuropathic, and structural pathways in prurigo nodularis (PN) to atopic dermatitis (AD), finding increased NGF and ECM remodeling in PN.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.

This paper develops an integrative deep learning model combining image, clinical, and genomic data to improve risk stratification for colon adenocarcinoma patients, showing better performance than models using single data types.

This study establishes a mouse model of post-traumatic joint injury and identifies Gli1+ mesenchymal progenitors as key contributors to arthrofibrosis and heterotopic ossification.

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.

This study compares transcriptome profiles of trypanotolerant and trypanosusceptible cattle breeds during Trypanosoma congolense infection, revealing differences in immune response and metabolic regulation.

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

The paper identifies 19 new quantitative trait loci (QTL) associated with susceptibility to Schistosoma mansoni infection in a murine backcross cohort, with two QTLs linked to granuloma number, liver lesion grade, and IgM levels.

This study shows that persistent macrophages after AKI promote a proinflammatory environment leading to tubule damage and CKD progression.

This study shows that higher active TGFβ1 levels in human subchondral bone correlate with cartilage loss and poor bone quality in knee OA.

scoMorphoFISH provides a deep-learning tool for spatial single-cell mRNA quantification and morphometry in kidney biopsies, enabling single-mRNA resolution analysis.

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

This paper develops an automated machine learning pipeline for differential cell counts on whole-slide bone marrow aspirate smears, showing high concordance with manual counts and reduced intra-slide variance.

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

This study shows that inhibiting ATR in C. elegans reduces the severity of mitochondrial ETC dysfunction by reversing nucleotide imbalances and restoring translation.